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Crohn’s Disease-associated variant in laccase domain containing 1 (LACC1) modulates T cell gene expression, metabolism and T cell function

Nature Communications(2025)10.1038/s41467-025-57744-3Source: DataRank Database

Crohn’s Disease-associated variant in laccase domain containing 1 (LACC1) modulates T cell gene expression, metabolism and T cell function is a research paper published in Nature Communications (2025). On theSindex it has a DataRank of 0. It has been cited 5 times.

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Open Access5 citations

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›Methodology & internals

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Enrichment:Funding (6 grants)Impact (FWCI 1.75)OA: goldTopics (40)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (9)

Gabriel Ascui ORCID,Martina Dicker,Thomas Riffelmacher ORCID,Vivek Chandra ORCID,Benjamin Joachim Schmiedel ORCID

Live enrichment

PubMed:40089498 PMC:PMC11910630 OpenAlex:https://openalex.org/W4408477391

U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases)

Grant: R01DK135683

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID)

Grant: U01AI125955

Wellcome Trust

Grant: 210842_Z_18_Z

U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases)

Grant: P01DK046763

NIAID NIH HHS

Grant: R24 AI108564

Wellcome Trust

Grant: 210842

FWCI

1.75

Citation Percentile

0.8%

Citation Trend

2025

2026

goldLicense: cc-by-nc-nd

journalhttps://doi.org/10.1038/s41467-025-57744-3

publisherhttps://doi.org/10.1038/s41467-025-57744-3

publisherhttps://www.nature.com/articles/s41467-025-57744-3.pdf

publisherhttps://www.nature.com/articles/s41467-025-57744-3

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40089498

Fields of Study

Neutrophil, Myeloperoxidase and Oxidative MechanismsMycobacterium research and diagnosisInflammatory Bowel DiseaseHumansCrohn DiseaseCD4-Positive T-LymphocytesPromoter Regions, GeneticGenome-Wide Association StudyGene Expression RegulationPolymorphism, Single NucleotideLaccaseGenetic Predisposition to DiseaseT-Lymphocytes, RegulatoryCell DifferentiationAlleles

MeSH Terms

AllelesCell DifferentiationCrohn DiseaseGene Expression RegulationHumansPromoter Regions, GeneticT-LymphocytesCD4-Positive T-LymphocytesGenetic Predisposition to DiseasePolymorphism, Single NucleotideLaccaseT-Lymphocytes, RegulatoryGenome-Wide Association Study

Keywords

Gene expressionFunction (biology)CellDiseaseGeneCell metabolismBiologyCell biologyComputational biologyGeneticsMedicineInternal medicine

Sustainable Development Goals

SDG 0: Zero hunger

Crohn’s Disease-associated variant in laccase domain containing 1 (LACC1) modulates T cell gene expression, metabolism and T cell function

FAIR Checklist

Authors (9)

Funding (6 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)