The EstroGene2.0 database for endocrine therapy response and resistance in breast cancer is a dataset published in npj Breast Cancer (2024). On theSindex it has a DataRank of 0.216, placing it in the top 63.1% of the data-sharing corpus. It has been cited 3 times, with 2 citing works in its 1-hop citation network. Its calibrated FAIR score is 46/100.
Ranks in the top 63% for downstream scientific impact
Linked data & code
DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?
FAIR checklist signals are shown for context only and do not affect DataRank scoring.
Full FAIR picture · advisory
The headline score is computed from the scored criteria — the fact-shaped checks (a repository, an accession, a licence) that two independent models agree on. The advisory criteria below are real FAIR guidance but rest on judgment calls that models read differently, so they inform without moving the number.
“https://estrogeneii.web.app/”
The database is identified only by a web URL, not a persistent identifier scheme. [majority verdict 'partial' (4/5 passes agreed)]
RDA-F1-01D — FAIR Data Maturity Model: 'Data is identified by a persistent identifier' (priorit · RDA-F1-02D — FAIR Data Maturity Model: 'Data is identified by a globally unique identifier' · FsF-F1-02D — F-UJI/FAIRsFAIR: 'Data is assigned a persistent identifier'
“EstroGene2.0 database”
The data are held on the project website, not a named repository. [majority verdict 'partial' (4/5 passes agreed)]
RDA-F4-01M — FAIR Data Maturity Model: metadata is offered so it can be harvested and indexed ( · NIH DMS Policy Element 4 (NOT-OD-21-014) — name the repository where data will be archived · NSTC Desirable Characteristics of Data Repositories (2022) — 'Long-Term Sustainability', 'Reten
“https://estrogeneii.web.app/”
The database URL appears only in the body text, not in the reference list.
FORCE11 Joint Declaration of Data Citation Principles (2014) — data should be cited as a first- · RDA-F3-01M — metadata clearly and explicitly includes the identifier of the data it describes · FsF-F3-01M — F-UJI: 'Metadata includes the identifier of the data it describes'
Advisory · not in the published score
“Details of all the curated all data sets used for database construction are summarized in Supplementary Data1.”
The data availability statement points to the supplementary data file, which is part of the article, not a repository record. [majority verdict 'partial' (4/5 passes agreed)]
Colavizza, Hrynaszkiewicz, Staden, Whitaker & McGillivray (2020), 'The citation advantage of li · Springer Nature research data policy — Data Availability Statements: standard statement templat · RDA-F3-01M — metadata clearly and explicitly includes the identifier of the data it describes
“The EstroGene2.0 database now encompasses multi-omic profiling data from 361 experiments across 212 studies, spanning 28 cell lines and publications from 2004 to 2023.”— not found in the paper; verdict downgraded
The dataset's content is described in running prose, but no itemised inventory is provided. [downgraded to 'no' — no verifiable quote from the paper] [majority verdict 'no' (3/5 passes agreed)]
RDA-F2-01M — 'Rich metadata is provided to allow discovery' (priority Essential) · FsF-F2-01M — F-UJI: 'Metadata includes descriptive core elements to support data findability' · FsF-R1-01MD — F-UJI: 'Metadata specifies the content of the data'
“a user-friendly browser offers comprehensive data visualization and metadata mining capabilities ( https://estrogeneii.web.app/).”
The database is available at the website with no stated precondition.
RDA-A1.1-01D — 'Data is accessible through a free access protocol' · FsF-A1-01M — F-UJI: 'Metadata contains access level and access conditions of the data' · NSTC Desirable Characteristics of Data Repositories (2022) — 'Free and Easy Access'
Advisory · not in the published score
“a user-friendly browser offers comprehensive data visualization and metadata mining capabilities ( https://estrogeneii.web.app/).”
The paper describes the database website but does not apply an explicit access-level label such as 'open access' to the data. [majority verdict 'partial' (4/5 passes agreed)]
FsF-A1-01M — F-UJI: 'Metadata contains access level and access conditions of the data' · RDA-A1-01M — metadata contains information to enable the user to get access to the data · COAR Controlled Vocabularies — Access Rights v1.0 (open / embargoed / restricted / metadata-onl
The study's data are from cell lines and public datasets, not sensitive human-subject data, and no gatekeeper is named.
NIH Genomic Data Sharing Policy (NOT-OD-14-124) — controlled-access via a Data Access Committee · RDA-A1.2-01D — 'Data is accessible through an access protocol that supports authentication and · NIH DMS Policy Element 5 (NOT-OD-21-014) — Access, Distribution, or Reuse Considerations (conse
The paper does not state how long the database will be retained or available. [majority verdict 'no' (4/5 passes agreed)]
NIH DMS Plan Element 4 (NOT-OD-21-014) — Data Preservation, Access, and Associated Timelines · NSTC Desirable Characteristics (2022), Organizational Infrastructure: 'Retention Policy' · RDA-A2-01M — 'Metadata is guaranteed to remain available after data is no longer available'
The paper does not name the file format of the released data.
FsF-R1.3-02D — F-UJI: 'Data is available in a file format recommended by the target research co · RDA-R1.3-02D — data is expressed in a machine-understandable community standard · RDA-I1-01D — data uses a knowledge representation expressed in a standardised format
Advisory · not in the published score
The paper does not state that the database complies with a community data or metadata standard.
RDA-R1.3-01M — 'Metadata complies with a community standard' (priority Essential) · RDA-R1.3-01D — 'Data complies with a community standard' · RDA-I2-01M — '(Meta)data use vocabularies that follow FAIR principles'
“GSE105777”
The paper cites GEO accession GSE105777 for the POETIC trial, a resource not produced by this study.
RDA-I3-01M — '(meta)data include references to other (meta)data' · RDA-I3-03M — 'metadata includes qualified references to other metadata' · FsF-I3-01M — F-UJI: 'Metadata includes links between the data and its related entities'
The paper's CC BY 4.0 license applies to the article, not the database itself.
RDA-R1.1-01M — 'Metadata includes information about the licence under which the data can be reu · RDA-R1.1-02M — 'Metadata refers to a standard reuse licence' · RDA-R1.1-03M — 'Metadata refers to a machine-understandable reuse licence'
“EstroGene2.0”
The database version is named as 'EstroGene2.0'. [majority verdict 'yes' (4/5 passes agreed)]
DataCite Metadata Schema 4.6 — the 'Version' property · RDA-R1.2-01M — provenance information (which version was used is provenance) · NSTC Desirable Characteristics of Data Repositories (2022) — 'Provenance', 'Retention Policy'
No code repository or locator is given for the study's own code.
NIH DMS Policy Element 2 (NOT-OD-21-014) — 'Related Tools, Software and/or Code' · FAIR4RS Principles v1.0 (Chue Hong et al., 2022; RDA/FORCE11/ReSA) — FAIR Principles for Resear · FORCE11 Software Citation Principles (Smith, Katz & Niemeyer, 2016, PeerJ CS 2:e86)
“R01CA221303”
The paper provides a specific grant number from the National Cancer Institute. [majority verdict 'yes' (4/5 passes agreed)]
DataCite Metadata Schema 4.6 — 'FundingReference' property (funderName, funderIdentifier, award · Crossref Funder Registry — canonical funder identifiers for funding metadata · RDA-F2-01M — rich metadata provided to allow discovery (funding is part of the descriptive reco
Advisory · not in the published score
“SRA runs are aligned to genome assembly GCA_000001405.15 (hg38) using HISAT2.”
The paper names specific software tools used to produce the data. [majority verdict 'yes' (3/5 passes agreed)]
RDA-R1.2-01M — 'Metadata includes provenance information according to community- specific standa · FsF-R1.2-01M — F-UJI: 'Metadata includes provenance information about data creation or generati · W3C PROV-O (W3C Recommendation, 2013) — the entity/activity/agent model of provenance
“All the relevant information is summarized in Supplementary Data1.”
The variable definitions live in the supplementary data file, which is part of the article, not shipped with the database. [majority verdict 'partial' (3/5 passes agreed)]
RDA-R1-01M — '(Meta)data are richly described with a plurality of accurate and relevant attribu · FsF-R1-01MD — F-UJI: 'Metadata specifies the content of the data' · NIH DMS Policy Element 3 (NOT-OD-21-014) — Standards (documentation and metadata to accompany t
Calibrated FAIR score — a parallel quality metric, independent of the DataRank citation score. See the full evaluation →
Base Score Contribution
0.208
From this paper's citation signal
Citation Network Contribution
7.86 × 10⁻³
From 1 citing papers with measurable signal
Ranked by each citer's contribution to N(p) — log1p(Cq) divided by its reference count — out of 2 citers.
Susan G. Komen
Grant: SAC110021
Susan G. Komen
Grant: SAC180085
Susan G. Komen
Grant: SAC160073
U.S. Department of Health & Human Services | NIH | National Cancer Institute
Grant: R01256161
U.S. Department of Health & Human Services | NIH | National Cancer Institute
Grant: R01CA251621
U.S. Department of Health & Human Services | NIH | National Cancer Institute
Grant: R01CA221303
Cancer Research UK
Grant: DRCPGM\100088
University of Cambridge
Grant: A20411, A31344, A29580
NCI NIH HHS
Grant: P30 CA047904
Cancer Research UK
Grant: 20411
NCI NIH HHS
Grant: R01 CA256161
NCI NIH HHS
Grant: R01 CA276089
NIH HHS
Grant: S10 OD028483
National Institutes of Health
Grant: 1R01CA276089-01
Manipulating normal estrogen physiology as a therapeutic approach in cancer
National Institutes of Health
Grant: 1R01CA251621-01A1
MDC1: central regulator of estrogen receptor function and therapy response in lobular carcinoma
National Institutes of Health
Grant: 1R01CA221303-01A1
Mechanism-based strategies to target ER-mutant endocrine resistant breast cancer
National Institutes of Health
Grant: 1S10OD028483-01A1
High-Throughput Computing for Genomics and Bioinformatics Research
Breast Cancer Research Foundation
Hutchison Whampoa Limited
FWCI
0.52
Citation Percentile
0.7%
Influential Citations
1
Citation Trend
Fields of Study
Keywords
Sustainable Development Goals