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UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressors

Nature(2025)10.1038/s41586-024-08532-4Source: DataRank Database

UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressors is a research paper published in Nature (2025). On theSindex it has a DataRank of 1.4. It has been cited 49 times, with 45 citing works in its 1-hop citation network.

N/A

1.4DataRank · unranked

Scored on demand from live citation data

Open Access49 citations · 45 citing works in its network

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Linked data & code

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DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (16 grants)Impact (FWCI 18.69)OA: hybridTopics (67)IDs (PubMed, PMC, OpenAlex)Annotations (4)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 43%Citation Network 57%

Base Score Contribution

0.587

From this paper's citation signal

Citation Network Contribution

0.790

From 29 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 45 citers.

Molecular glue unexpectedly mimics the effect of cancer mutations
Nature20253 citations8 referencesContributes 0.173
YDS-GlueFold: Surpassing AlphaFold 3-Type Models for Molecular Glue-Induced Ternary Complex Prediction
bioRxiv (Cold Spring Harbor Laboratory)20249 citations16 referencesContributes 0.144
Mutations that stick: Unexpected discovery of molecular glue mimicry
Molecular Cell20251 citations11 referencesContributes 0.063
Primed for degradation: How weak protein interactions enable molecular glue degraders
Current Opinion in Structural Biology202511 citations54 referencesContributes 0.046
Fisetin attenuates lipopolysaccharide-induced neuroinflammation by modulating the histone deacetylase 3–nuclear factor erythroid 2–related factor 2 axis
Food Bioscience20257 citations57 referencesContributes 0.036

Authors (32)

Olivia Zhang ORCID,Xiaowen Xie ORCID,Eunju Nam ORCID,N. Connor Payne ORCID,Pallavi M. Gosavi ORCID

Live enrichment

PubMed:39939761 PMC:PMC11882444 OpenAlex:https://openalex.org/W4407392239

NCI NIH HHS

Grant: R01 CA274437

NIGMS NIH HHS

Grant: R35 GM149229

NCI NIH HHS

Grant: U01 CA271402

NIGMS NIH HHS

Grant: DP2 GM137494

NCI NIH HHS

Grant: P01 CA206978

NIGMS NIH HHS

Grant: R35 GM153476

NCI NIH HHS

Grant: U24 CA270823

Fundação para a Ciência e a Tecnologia, I.P.

Grant: PTDC/CCI-INF/6762/2020

MS3: New foundations for micro-services and serverless systems

National Institutes of Health

Grant: 5U24CA270823-02

Center of Excellence for High Throughput Proteogenomic Characterization

National Institutes of Health

Grant: 5R35GM149229-02

Chemical Approaches to Understanding Reversible Lysine Modifications

National Institutes of Health

Grant: 1DP2GM137494-01

Mapping Structure-Activity Relationships of Chemical Inhibitors via Genome-Editing

National Science Foundation

Grant: 1745303

Graduate Research Fellowship Program (GRFP)

National Institutes of Health

Grant: 5P01CA206978-05

Comprehensive dissection of the CLL genome and phenome to improve patient outcomes

National Institutes of Health

Grant: 1R35GM153476-01

Integrating Chemical Genetic Approaches with Precision Genome Editing

National Institutes of Health

Grant: 5R01CA274437-02

Chemical Genetic Approaches to Study Chromatin Complexes

National Institutes of Health

Grant: 5U01CA271402-04

Proteogenomic Predictors of Recurrence in Non-small Cell Lung Cancer

FWCI

18.69

Citation Percentile

1.0%

Citation Trend

2024

2025

2026

hybridLicense: cc-by

journalhttps://doi.org/10.1038/s41586-024-08532-4

publisherhttps://doi.org/10.1038/s41586-024-08532-4

publisherhttps://www.nature.com/articles/s41586-024-08532-4.pdf

publisherhttps://www.nature.com/articles/s41586-024-08532-4

repositoryhttps://pubmed.ncbi.nlm.nih.gov/39939761

Fields of Study

Protein Degradation and InhibitorsHistone Deacetylase Inhibitors ResearchEpigenetics and DNA Methylation0301 basic medicine03 medical and health sciencesHumansCatalytic DomainCo-Repressor ProteinsCryoelectron MicroscopyHistone Deacetylase 1Histone Deacetylase 2Models, MolecularProtein BindingProteolysisUbiquitin-Protein LigasesIndolesPyrimidinesCarrier ProteinsHistone Demethylases

MeSH Terms

Carrier ProteinsHumansIndolesModels, MolecularNerve Tissue ProteinsProtein BindingPyrimidinesCatalytic DomainCryoelectron MicroscopyUbiquitin-Protein LigasesProtein MultimerizationHistone Deacetylase 1Histone Deacetylase 2Histone DemethylasesCo-Repressor ProteinsNuclear Receptor Co-Repressor 2Proteolysis

Keywords

CorepressorCell biologyUbiquitin ligaseChemistryHDAC1BiochemistryBiologyUbiquitinTranscription factorRepressorModels, MolecularHistone Demethylases570Indoleshistone modificationsUbiquitin-Protein LigasesCryoelectron MicroscopyHistone Deacetylase 2Histone Deacetylase 1protein degrader540ArticlePyrimidinesCatalytic DomainProteolysiscancerHumansEpigeneticsCarrier ProteinsCo-Repressor ProteinsProtein Binding