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Characterizing the molecular regulation of inhibitory immune checkpoints with multimodal single-cell screens

Nature Genetics(2021)10.1038/s41588-021-00778-2Source: DataRank Database

Characterizing the molecular regulation of inhibitory immune checkpoints with multimodal single-cell screens is a research paper published in Nature Genetics (2021). On theSindex it has a DataRank of 5.7. It has been cited 256 times, with 200 citing works in its 1-hop citation network.

N/A

5.7DataRank · unranked

Scored on demand from live citation data

Open Access256 citations · 200 citing works in its network

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Linked data & code

geo gen doi

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (9 grants)Impact (FWCI 15.96)OA: greenTopics (70)IDs (PubMed, PMC, OpenAlex)Annotations (3)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 14%Citation Network 86%

Base Score Contribution

0.832

From this paper's citation signal

Citation Network Contribution

4.9

From 182 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 200 citers.

Completing the cancer jigsaw puzzle with single-cell multiomics
Nature Cancer20217 citations14 referencesContributes 0.149
MultiCPA: Multimodal Compositional Perturbation Autoencoder
bioRxiv (Cold Spring Harbor Laboratory)202217 citations20 referencesContributes 0.145
Predicting cellular responses to complex perturbations in high‐throughput screens
Molecular Systems Biology2023282 citations46 referencesContributes 0.123
PRDM1/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells
Nature Communications2022122 citations42 referencesContributes 0.115
A Supervised Contrastive Framework for Learning Disentangled Representations of Cell Perturbation Data
bioRxiv (Cold Spring Harbor Laboratory)20248 citations21 referencesContributes 0.105

Authors (11)

Eleni P. Mimitou ORCID,Andrew Butler ORCID,Samantha D. Foster,Bernadette Bracken,William M. Mauck ORCID

Live enrichment

PubMed:33649593 PMC:PMC8011839 OpenAlex:https://openalex.org/W3133712085

U.S. Department of Health & Human Services | National Institutes of Health

Grant: DP2HG009623-01

U.S. Department of Health & Human Services | National Institutes of Health

Grant: RM1HG011014-01

U.S. Department of Health & Human Services | National Institutes of Health

Grant: R21HG009748-03

NHGRI NIH HHS

Grant: R21 HG009748

NHGRI NIH HHS

Grant: DP2 HG009623

NHGRI NIH HHS

Grant: RM1 HG011014

National Institutes of Health

Grant: 1DP2HG009623-01

Learning the metadata of the cell with single cell genomics

National Institutes of Health

Grant: 1R21HG009748-01

Massively Parallel Multi-Modal Single-Cell Phenotyping Using a Portable Device

National Institutes of Health

Grant: 5RM1HG011014-02

Center for Integrated Cellular Analysis

FWCI

15.96

Citation Percentile

1.0%

Citation Trend

2020

2021

2022

2023

2024

2025

2026

greenLicense: Springer TDM

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8011839

publisherhttp://www.nature.com/articles/s41588-021-00778-2.pdf

publisherhttp://www.nature.com/articles/s41588-021-00778-2

journalhttps://doi.org/10.1038/s41588-021-00778-2

Fields of Study

Single-cell and spatial transcriptomicsCRISPR and Genetic EngineeringGene Regulatory Network Analysis0301 basic medicine0303 health sciences03 medical and health sciencesB7-2 AntigenB7-H1 AntigenCell Cycle ProteinsClustered Regularly Interspaced Short Palindromic RepeatsCullin ProteinsHumansImmune Checkpoint ProteinsKelch-Like ECH-Associated Protein 1NF-E2-Related Factor 2Programmed Cell Death 1 Ligand 2 ProteinReceptors, InterferonReproducibility of ResultsSignal-To-Noise RatioSingle-Cell AnalysisTHP-1 CellsTranscription FactorsBromodomain Containing Proteins

MeSH Terms

Kelch-Like ECH-Associated Protein 1THP-1 CellsImmune Checkpoint ProteinsBromodomain Containing ProteinsHumansTranscription FactorsReproducibility of ResultsReceptors, InterferonCell Cycle ProteinsCullin ProteinsNF-E2-Related Factor 2B7-2 AntigenSingle-Cell AnalysisSignal-To-Noise RatioB7-H1 AntigenProgrammed Cell Death 1 Ligand 2 ProteinClustered Regularly Interspaced Short Palindromic Repeats

Keywords

BiologyCRISPRComputational biologyImmune systemCellDownregulation and upregulationCell biologyTranscriptional regulationSignal transductionTranscription factorGeneticsGeneKelch-Like ECH-Associated Protein 1NF-E2-Related Factor 2THP-1 CellsReproducibility of ResultsCell Cycle ProteinsSignal-To-Noise RatioCullin ProteinsImmune Checkpoint ProteinsProgrammed Cell Death 1 Ligand 2 ProteinArticleB7-H1 AntigenBromodomain Containing ProteinsHumansClustered Regularly Interspaced Short Palindromic RepeatsB7-2 AntigenSingle-Cell AnalysisReceptors, InterferonTranscription Factors

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being