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Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain

Nature Chemical Biology(2021)10.1038/s41589-021-00815-5Source: DataRank Database

Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain is a research paper published in Nature Chemical Biology (2021). On theSindex it has a DataRank of 1.8. It has been cited 67 times, with 61 citing works in its 1-hop citation network.

N/A

1.8DataRank · unranked

Scored on demand from live citation data

Open Access67 citations · 61 citing works in its network

Cite:

Linked data & code

geo pdb

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (19 grants)Impact (FWCI 3.80)OA: bronzeTopics (41)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 35%Citation Network 65%

Base Score Contribution

0.633

From this paper's citation signal

Citation Network Contribution

1.2

From 53 citing papers with measurable signal

Learn more about DataRank methodology →

Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 61 citers.

Fighting PRC1 via the RING
Nature Chemical Biology20212 citations8 referencesContributes 0.137
Targeted Degradation of PRC1 Components, BMI1 and RING1B, via a Novel Protein Complex Degrader Strategy
Advanced Science202328 citations46 referencesContributes 0.073
Discovery and Characterization of a Novel Cereblon-Recruiting PRC1 Bridged PROTAC Degrader
Journal of Medicinal Chemistry202411 citations34 referencesContributes 0.073
Synthetic E2-Ub-nucleosome conjugates for studying nucleosome ubiquitination
Chem202358 citations57 referencesContributes 0.072
Human Serum Albumin Based Nanodrug Delivery Systems: Recent Advances and Future Perspective
Polymers202369 citations78 referencesContributes 0.054

Authors (25)

Weijiang Ying,Felicia Gray,Yiwu Yao ORCID,Miranda L. Simes ORCID,Qingjie Zhao

Live enrichment

PubMed:34155404 PMC:PMC8238916 OpenAlex:https://openalex.org/W3177272482

U.S. Department of Health & Human Services | NIH | National Cancer Institute

Grant: CA201204

U.S. Department of Health & Human Services | NIH | National Cancer Institute

Grant: CA244254

U.S. Department of Health & Human Services | NIH | National Cancer Institute

Grant: CA160467

U.S. Department of Health & Human Services | NIH | National Cancer Institute

Grant: CA226759

U.S. Department of Health & Human Services | NIH | National Cancer Institute

Grant: CA240514

Leukemia and Lymphoma Society

Grant: 1340-17

NCI NIH HHS

Grant: R01 CA160467

NCI NIH HHS

Grant: R01 CA207272

NCI NIH HHS

Grant: K08 CA208013

NCI NIH HHS

Grant: R01 CA226759

NCI NIH HHS

Grant: R01 CA244254

NCI NIH HHS

Grant: R01 CA201204

NCI NIH HHS

Grant: R01 CA240514

National Institutes of Health

Grant: 1R01CA160467-01

Development of novel anti-leukemia agents targeting the menin-MLL interaction

National Institutes of Health

Grant: 5R01CA226759-02

Targeting NSD1 in leukemia

National Institutes of Health

Grant: 5R01CA240514-03

Targeting epigenetic reader GAS41

National Institutes of Health

Grant: 5R01CA207272-03

Development of small molecules targeting Ring1B-Bmi1 E3 ligase in leukemia

National Institutes of Health

Grant: 5R01CA244254-05

Development of ASH1L inhibitors for acute leukemia

National Institutes of Health

Grant: 5R01CA201204-02

Targeting protein-protein interactions of Bmi1 oncoprotein

FWCI

3.80

Citation Percentile

1.0%

Citation Trend

2021

2022

2023

2024

2025

2026

bronzeLicense: Springer TDM

journalhttps://www.nature.com/articles/s41589-021-00815-5.pdf

publisherhttps://www.nature.com/articles/s41589-021-00815-5.pdf

publisherhttps://www.nature.com/articles/s41589-021-00815-5

journalhttps://doi.org/10.1038/s41589-021-00815-5

repositoryhttps://pubmed.ncbi.nlm.nih.gov/34155404

Fields of Study

Epigenetics and DNA MethylationMicrotubule and mitosis dynamicsCancer-related gene regulation0301 basic medicine03 medical and health sciencesCell DifferentiationDose-Response Relationship, DrugHumansK562 CellsModels, MolecularMolecular StructurePolycomb Repressive Complex 1Small Molecule LibrariesUbiquitination

MeSH Terms

Cell DifferentiationDose-Response Relationship, DrugHumansModels, MolecularMolecular StructureK562 CellsSmall Molecule LibrariesUbiquitinationPolycomb Repressive Complex 1

Keywords

Domain (mathematical analysis)Ring (chemistry)Small moleculeComputational biologyChemistryCell biologyBiologyBiochemistryModels, MolecularPolycomb Repressive Complex 1Small Molecule LibrariesDose-Response Relationship, DrugMolecular StructureUbiquitinationHumansCell DifferentiationK562 CellsArticle

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

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