🏆 Finalist — NIH Data Sharing Index (“S-Index”) Challenge

Pilot corpus: NIH-funded biomedical datasets. Any DOI can be scored on demand — network effects sharpen as coverage grows.

M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome

Nature Chemical Biology(2022)10.1038/s41589-021-00964-7Source: DataRank Database

M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome is a research paper published in Nature Chemical Biology (2022). On theSindex it has a DataRank of 0. It has been cited 37 times.

N/A

0DataRank · unranked

Scored on demand from live citation data

Open Access37 citations

Cite:

Linked data & code

gen hpa pxd doi

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (20 grants)Impact (FWCI 3.07)OA: greenTopics (41)IDs (PubMed, PMC, OpenAlex)Annotations (4)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

FAIR checklist signals are shown for context only and do not affect DataRank scoring.

Run a calibrated FAIR evaluation for this paper →

We only score data papers we can read in full — never from an abstract alone.

Authors (14)

Qifeng Chen ORCID,Qinghui Wang ORCID,Elizabeth L. Orth-He ORCID,Michelle Saoi ORCID,Andrew R. Griswold ORCID

Live enrichment

PubMed:35165443 PMC:PMC9179932 OpenAlex:https://openalex.org/W4212834056

U.S. Department of Health & Human Services | National Institutes of Health

Grant: T32 GM115327-Tan

U.S. Department of Health & Human Services | National Institutes of Health

Grant: F30 CA008748

U.S. Department of Health & Human Services | National Institutes of Health

Grant: T32 GM007739-Andersen

U.S. Department of Health & Human Services | National Institutes of Health

Grant: R25AI140472

U.S. Department of Health & Human Services | National Institutes of Health

Grant: R01 AI163170

U.S. Department of Health & Human Services | National Institutes of Health

Grant: P30 CA008748

Pew Charitable Trusts

Grant: N/A

NIGMS NIH HHS

Grant: T32 GM115327

NCI NIH HHS

Grant: F30 CA243444

NIGMS NIH HHS

Grant: T32 GM007739

NIAID NIH HHS

Grant: R01 AI137168

National Institutes of Health

Grant: 5R25AI140472-02

Tri-I Training Program in Metabolomics

National Institutes of Health

Grant: 5R01AI163170-05

Redox control of the NLRP1 inflammasome

Fundação para a Ciência e a Tecnologia, I.P.

Grant: PTDC/CCI-INF/6762/2020

MS3: New foundations for micro-services and serverless systems

National Institutes of Health

Grant: 5R01AI137168-08

Characterizing the Mechanism of DPP8/9 Inhibitor-Induced Pyroptosis

National Institutes of Health

Grant: 2P30CA008748-43

MOUSE GENETICS

National Institutes of Health

Grant: 1T32GM115327-01

Tri-Institutional PhD Program in Chemical Biology

National Institutes of Health

Grant: 5T32GM007739-30

Weill Cornell/Rockefeller/Sloan-Kettering MST Program

Mr. William H and Mrs. Alice Goodwin, the Commonwealth Foundation for Cancer Research, and The Center for Experimental Therapeutics of Memorial Sloan Kettering Cancer Center; the Emerson Collective

Marie-Josée Kravis Women in Science Endeavor (WISE) fellowship

FWCI

3.07

Citation Percentile

0.9%

Citation Trend

2022

2023

2024

2025

2026

greenLicense: Springer TDM

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/9179932

GREENhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179932

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/9179932

publisherhttps://www.nature.com/articles/s41589-021-00964-7.pdf

publisherhttps://www.nature.com/articles/s41589-021-00964-7

Fields of Study

Peptidase Inhibition and AnalysisSignaling Pathways in DiseaseGalectins and Cancer BiologyMedicineChemistry0301 basic medicine0303 health sciences03 medical and health sciencesAminopeptidasesApoptosis Regulatory ProteinsCARD Signaling Adaptor ProteinsInflammasomesNeoplasm ProteinsProline

MeSH Terms

AminopeptidasesNeoplasm ProteinsProlineApoptosis Regulatory ProteinsCARD Signaling Adaptor ProteinsInflammasomes

Keywords

InflammasomeAminopeptidaseIntracellularEnzymeDipeptidyl peptidaseNLRP1BiochemistryBiologyPeptideCell biologyChemistryAmino acidReceptorCaspaseLeucineCARD Signaling Adaptor ProteinsProlineInflammasomesApoptosis Regulatory ProteinsAminopeptidasesNeoplasm Proteins

Sustainable Development Goals

SDG 3: 3. Good health

Related Papers (6)

Highly accurate protein structure prediction with AlphaFold

N/A

1.6DataRank · unranked

Nature(2021)

co-cited

10.1038/s41586-021-03819-2

Caspase-1 interdomain linker cleavage is required for pyroptosis

Life Science Alliance(2020)

co-cited

10.26508/lsa.202000664

Activation of the CARD8 Inflammasome Requires a Disordered Region

N/A

0.609DataRank · unranked

Cell Reports(2020)

co-cited

10.1016/j.celrep.2020.108264

Diverse viral proteases activate the NLRP1 inflammasome

eLife(2021)

co-cited

10.7554/elife.60609

A ubiquitin-independent proteasome pathway controls activation of the CARD8 inflammasome

N/A

0.477DataRank · unranked

Journal of Biological Chemistry(2022)

co-cited

10.1016/j.jbc.2022.102032

The NLRP1 and CARD8 inflammasomes detect reductive stress

N/A

0.416DataRank · unranked

bioRxiv (Cold Spring Harbor Laboratory)(2022)

co-cited

10.1101/2022.03.22.485209