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Analysis of combinatorial CRISPR screens with the Orthrus scoring pipeline

Nature Protocols(2021)10.1038/s41596-021-00596-0Source: DataRank Database

Analysis of combinatorial CRISPR screens with the Orthrus scoring pipeline is a research paper published in Nature Protocols (2021). On theSindex it has a DataRank of 0.556. It has been cited 17 times, with 7 citing works in its 1-hop citation network.

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0.556DataRank · unranked

Scored on demand from live citation data

Open Access17 citations · 7 citing works in its network

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (13 grants)OA: hybridTopics (10)IDs (PubMed)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 78%Citation Network 22%

Base Score Contribution

0.434

From this paper's citation signal

Citation Network Contribution

0.123

From 6 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 7 citers.

Common computational tools for analyzing CRISPR screens
Emerging Topics in Life Sciences202113 citations80 referencesContributes 0.033
A multilineage screen identifies actionable synthetic lethal interactions in human cancers
Nature Genetics202415 citations91 referencesContributes 0.030
Benchmarking Genetic Interaction Scoring Methods for Identifying Synthetic Lethality from Combinatorial CRISPR Screens
bioRxiv (Cold Spring Harbor Laboratory)20251 citations26 referencesContributes 0.027
Benchmarking genetic interaction scoring methods for identifying synthetic lethality from combinatorial CRISPR screens
NAR Genomics and Bioinformatics20251 citations32 referencesContributes 0.022
Analysis of Combinatorial Knockout CRISPR Screens with GRAPE: Genetic interaction Regression Analysis of Pairwise Effects
bioRxiv (Cold Spring Harbor Laboratory)20261 citations35 referencesContributes 0.020

Authors (9)

Michael Aregger ORCID,Thomas Gonatopoulos-Pournatzis ORCID,Maximilian Billmann ORCID,Toshiro K. Ohsumi ORCID,Kevin R. Brown ORCID

Live enrichment

PubMed:19162232

National Science Foundation

Grant: 1818293

Large-scale mapping of genetic interactions across diverse cell types

U.S. Department of Health & Human Services | National Institutes of Health

Grant: R01HG005084

U.S. Department of Health & Human Services | National Institutes of Health

Grant: R01HG005853

U.S. Department of Health & Human Services | National Institutes of Health

Grant: T32GM008347

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Grant: P300PA_164667

Gouvernement du Canada | Canadian Institutes of Health Research

Grant: FDN-148434

Gouvernement du Canada | Canadian Institutes of Health Research

Grant: MOP-142375

Genome Canada

Grant: OGI-157

Canadian Institutes of Health Research

Grant: unidentified

unidentified

National Institutes of Health

Grant: 2T32GM008347-16A1

Training for Future Biotechnology Development

National Institutes of Health

Grant: 1R01HG005853-01

Mapping the reference genetic network of a eukaryotic cell

Swiss National Science Foundation

Grant: 164667

Identification of genetic networks required for reprogramming of cancer cells in response to metabolic stress using next-generation CRISPR-Cas9 screens

National Institutes of Health

Grant: 5R01HG005084-03

Computational Strategies for Quantitative Mapping of Genetic Interaction Networks

hybridLicense: cc-by

publisherhttps://doi.org/10.1038/s41596-021-00596-0

publisherhttps://www.nature.com/articles/s41596-021-00596-0.pdf

publisherhttps://www.nature.com/articles/s41596-021-00596-0

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/9084619

https://pubmed.ncbi.nlm.nih.gov/34508259

Fields of Study

0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

Gene EditingAnimalsComputational BiologyClustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Cas SystemsRNA, Guide, CRISPR-Cas SystemsSoftware