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A multiscale approach for bridging the gap between potency, efficacy, and safety of small molecules directed at membrane proteins

Scientific Reports(2021)10.1038/s41598-021-96217-7Source: DataRank Database

A multiscale approach for bridging the gap between potency, efficacy, and safety of small molecules directed at membrane proteins is a research paper published in Scientific Reports (2021). On theSindex it has a DataRank of 0. It has been cited 24 times.

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Open Access24 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (8 grants)OA: goldTopics (62)IDs (PubMed)SDGs (1)

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Authors (8)

Jeffery Creech ORCID,Eric N. Jiménez‐Vázquez ORCID,Guadalupe Guerrero‐Serna ORCID,Nulang Wang,André Monteiro da Rocha ORCID

Live enrichment

PubMed:34400719

American Heart Association

Grant: 19POST34380706

National Institute for Environmental Studies

Grant: R44ES027703

National Heart, Lung, and Blood Institute

Grant: R01HL148068

National Institute of General Medical Sciences

Grant: R01GM120142

Michigan Drug Discovery

Grant: MDD2019202

National Institutes of Health

Grant: 3R01GM120142-05S1

Molecular mechanisms and regulation of the calcium pump in the heart

National Institutes of Health

Grant: 5R44ES027703-03

hiPSC Cardiomyocyte HTS Electrophysiology System for Detecting Drug Induced Fatal Cardiac Arrhythmias

National Institutes of Health

Grant: 5R01HL148068-02

Hit-to-lead optimization for heart failure drug discovery

goldLicense: CC BY

publisherhttps://www.nature.com/articles/s41598-021-96217-7.pdf

publisherhttps://www.nature.com/articles/s41598-021-96217-7

https://doi.org/10.1038/s41598-021-96217-7

https://pubmed.ncbi.nlm.nih.gov/34400719

http://dx.doi.org/10.1038/s41598-021-96217-7

Fields of Study

0301 basic medicine03 medical and health sciences0303 health sciencesAnimalsEnzyme ActivationGiant CellsHumansInduced Pluripotent Stem CellsMembrane ProteinsMicrosomesMolecular Dynamics SimulationMolecular StructureMolecular Targeted TherapyMyocytes, CardiacPhosphatidylcholinesProtein DomainsSarcoplasmic ReticulumSarcoplasmic Reticulum Calcium-Transporting ATPasesSmall Molecule LibrariesSwineWater

MeSH Terms

AnimalsEnzyme ActivationGiant CellsHumansInduced Pluripotent Stem CellsMembrane ProteinsMicrosomesMolecular Dynamics SimulationMolecular StructureMolecular Targeted TherapyMyocytes, CardiacPhosphatidylcholinesProtein DomainsSarcoplasmic ReticulumSarcoplasmic Reticulum Calcium-Transporting ATPasesSmall Molecule LibrariesSwineWater

Keywords

SwineScienceInduced Pluripotent Stem CellsMolecular Dynamics SimulationGiant CellsArticleSarcoplasmic Reticulum Calcium-Transporting ATPasesSmall Molecule LibrariesProtein DomainsMicrosomesAnimalsHumansMyocytes, CardiacMolecular Targeted TherapyMolecular StructureQRMembrane ProteinsWaterEnzyme ActivationSarcoplasmic ReticulumPhosphatidylcholinesMedicine

Sustainable Development Goals

SDG 3: 3. Good health