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Cardiac myosin inhibitor, CK-586, minimally reduces systolic function and ameliorates obstruction in feline hypertrophic cardiomyopathy

Scientific Reports(2024)10.1038/s41598-024-62840-3Source: DataRank Database

Cardiac myosin inhibitor, CK-586, minimally reduces systolic function and ameliorates obstruction in feline hypertrophic cardiomyopathy is a research paper published in Scientific Reports (2024). On theSindex it has a DataRank of 0.223. It has been cited 3 times, with 3 citing works in its 1-hop citation network.

N/A

0.223DataRank · unranked

Scored on demand from live citation data

Open Access3 citations · 3 citing works in its network

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (18 grants)Impact (FWCI 0.88)OA: goldTopics (81)IDs (PubMed, PMC, OpenAlex)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 93%Citation Network 7%

Base Score Contribution

0.208

From this paper's citation signal

Citation Network Contribution

0.0147

From 2 citing papers with measurable signal

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Top 3 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 3 citers.

Clinical-Diagnostic and Therapeutic Advances in Feline Hypertrophic Cardiomyopathy
Veterinary Sciences20257 citations183 referencesContributes 0.011
Experimental Models of Hypertrophic Cardiomyopathy
JACC Basic to Translational Science20258 citations369 referencesContributes 0.006
Cardiac myosin inhibitors - a cutting-edge solution for the management of hypertrophic cardiomyopathy: a narrative review
Annals of Medicine and Surgery20250 citations60 referencesContributes 0.000

Authors (13)

Amanda E. Crofton ORCID,Carina E. Jauregui ORCID,Jalena R. Wouters,Betty S. Yang,Luke A. Wittenburg ORCID

Live enrichment

PubMed:38802475 PMC:PMC11130313 OpenAlex:https://openalex.org/W4399053555

National Heart, Lung, and Blood Institute

Grant: HL086350

National Center for Advancing Translational Sciences

Grant: TR001861

National Institute of General Medical Sciences

Grant: GM136469

NIH Office of the Director

Grant: OD026526

NIH Office of the Director

Grant: OD011147

Morris Animal Foundation

Grant: D22FE-027

NCATS NIH HHS

Grant: TL1 TR001861

NIH HHS

Grant: K01 OD026526

NHLBI NIH HHS

Grant: T32 HL086350

NIGMS NIH HHS

Grant: T34 GM136469

NIH HHS

Grant: T32 OD011147

NIGMS NIH HHS

Grant: T32 GM136559

National Institutes of Health

Grant: 2TL1TR001861-06

NRSA Training Core (TL1)

National Institutes of Health

Grant: 5K01OD026526-05

Defining the role of core binding factor protein interactions in osteosarcoma

National Institutes of Health

Grant: 2T32HL086350-16A1

Training Program in Basic and Translational Cardiovascular Science

National Institutes of Health

Grant: 5T34GM136469-02

MARC at University of California, Davis

National Institutes of Health

Grant: 5T32OD011147-35

Comparative Medical Science Training Program

Cytokinetics

FWCI

0.88

Citation Percentile

0.8%

Citation Trend

2025

goldLicense: cc-by

journalhttps://www.nature.com/articles/s41598-024-62840-3.pdf

publisherhttps://www.nature.com/articles/s41598-024-62840-3.pdf

publisherhttps://www.nature.com/articles/s41598-024-62840-3

journalhttps://doi.org/10.1038/s41598-024-62840-3

repositoryhttps://pubmed.ncbi.nlm.nih.gov/38802475

Fields of Study

Cardiomyopathy and Myosin StudiesCardiovascular Conditions and TreatmentsCardiovascular Effects of Exercise0403 veterinary science03 medical and health sciences0302 clinical medicine04 agricultural and veterinary sciencesAnimalsCatsCardiomyopathy, HypertrophicCardiac MyosinsCat DiseasesMaleFemaleVentricular Outflow ObstructionSystoleEchocardiographyCross-Over Studies

MeSH Terms

AnimalsCardiomyopathy, HypertrophicCat DiseasesCatsEchocardiographyFemaleMaleSystoleVentricular Outflow ObstructionCross-Over StudiesCardiac Myosins

Keywords

MedicineHypertrophic cardiomyopathyVentricular outflow tract obstructionPharmacodynamicsCardiologyCATSCardiomyopathyInternal medicineCrossover studySarcomereHeart failurePathologyPlaceboMyocytePharmacokineticscatLeft Ventricular Outflow Tract Obstruction (Lvoto)Obstructive Hypertrophic Cardiomyopathy (Ohcm)Myosin-inhibitorMaleSystoleScienceClinical Trials and Supportive Activities610Veterinary and Food SciencesCardiovascularCat DiseasesArticleVentricular Outflow ObstructionRare DiseasesClinical Research617Obstructive hypertrophic cardiomyopathyAnimalsVeterinary SciencesLeft ventricular outflow tract obstructionPediatricAgriculturalCross-Over StudiesBiomedical and Clinical SciencesQRCardiomyopathy, HypertrophicOrphan DrugHeart Disease5.1 PharmaceuticalsHypertrophicEchocardiography6.1 PharmaceuticalsFemalePediatric CardiomyopathyCardiac Myosins

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being