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Discovery of the DNA-PKcs inhibitor DA-143 which exhibits enhanced solubility relative to NU7441

Scientific Reports(2024)10.1038/s41598-024-70858-wSource: DataRank Database

Discovery of the DNA-PKcs inhibitor DA-143 which exhibits enhanced solubility relative to NU7441 is a research paper published in Scientific Reports (2024). On theSindex it has a DataRank of 0. It has been cited 3 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access3 citations

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Linked data & code

gen uniprot pdb

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (2 grants)Impact (FWCI 0.47)OA: goldTopics (32)IDs (PubMed, PMC, OpenAlex)Annotations (3)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (12)

Baku Acharya ORCID,Daniel W. Armstrong ORCID,Maha Hanafi,Randall R Rainwater ORCID,Sharon Amole

Live enrichment

PubMed:39198533 PMC:PMC11358143 OpenAlex:https://openalex.org/W4401949625

National Institutes of Health

Grant: P20GM109005

NIAID NIH HHS

Grant: R21 AI173759

FWCI

0.47

Citation Percentile

0.6%

Citation Trend

2025

2026

goldLicense: cc-by-nc-nd

journalhttps://www.nature.com/articles/s41598-024-70858-w.pdf

publisherhttps://www.nature.com/articles/s41598-024-70858-w.pdf

publisherhttps://www.nature.com/articles/s41598-024-70858-w

journalhttps://doi.org/10.1038/s41598-024-70858-w

repositoryhttps://pubmed.ncbi.nlm.nih.gov/39198533

Fields of Study

DNA Repair MechanismsDNA and Nucleic Acid ChemistryPARP inhibition in cancer therapyHumansDNA-Activated Protein KinaseSolubilityMorpholinesProtein Kinase InhibitorsChromonesCell Line, TumorDNA DamageT-Lymphocytes

MeSH Terms

ChromonesDNA DamageHumansMorpholinesSolubilityT-LymphocytesCell Line, TumorProtein Kinase InhibitorsDNA-Activated Protein Kinase

Keywords

SolubilityDNADrug discoveryComputer scienceChemistryComputational biologyMaterials scienceMedicineBiologyBiochemistryPhysical chemistry