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A multi-ethnic genome-wide association study implicates collagen matrix integrity and cell differentiation pathways in keratoconus

Communications Biology(2021)10.1038/s42003-021-01784-0Source: DataRank Database

A multi-ethnic genome-wide association study implicates collagen matrix integrity and cell differentiation pathways in keratoconus is a research paper published in Communications Biology (2021). On theSindex it has a DataRank of 2.0. It has been cited 95 times, with 76 citing works in its 1-hop citation network.

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2.0DataRank · unranked

Scored on demand from live citation data

Open Access95 citations · 76 citing works in its network

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (30 grants)OA: goldTopics (73)IDs (PubMed)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 34%Citation Network 66%

Base Score Contribution

0.685

From this paper's citation signal

Citation Network Contribution

1.3

From 56 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 76 citers.

Genetic variants in the FOXO1 and ZNF469 genes are associated with keratoconus in Sweden: a case-control study
BMC Ophthalmology20244 citations22 referencesContributes 0.073
Japanese 17q12 Deletion Syndrome with Complex Clinical Manifestations
Internal Medicine20244 citations26 referencesContributes 0.062
Collagen type XII is undetectable in keratoconus Bowman’s layer
British Journal of Ophthalmology20238 citations37 referencesContributes 0.059
Vernal keratoconjunctivitis and keratoconus
Current Opinion in Allergy and Clinical Immunology202150 citations68 referencesContributes 0.058
Intergenic variants, rs1200114 and rs1200108 are genetically associated along with a decreased ATP1B1 expression in Fuchs Endothelial Corneal Dystrophy
Experimental Eye Research20235 citations35 referencesContributes 0.051

Authors (62)

Petra Liskova ORCID,Yelena Bykhovskaya,Bennet J. McComish ORCID,Alice E. Davidson ORCID,Chris F. Inglehearn ORCID

Live enrichment

PubMed:33649486

National Institutes of Health

Grant: 5UL1TR000124-04

UCLA Clinical and Translational Science Institute

National Health and Medical Research Council (NHMRC)

Grant: 1138585

Pathways to precision medicine in eye disease

National Health and Medical Research Council (NHMRC)

Grant: 1104700

Gene Identification for Keratoconus - a Blinding Eye Disease

National Health and Medical Research Council (NHMRC)

Grant: 1150144

Translating genetic determinants of glaucoma into better diagnosis and treatment

National Health and Medical Research Council (NHMRC)

Grant: 1059954

Molecular genetic risk factors and mechanisms in blinding eye disease

National Institutes of Health

Grant: 5R01EY009052-13

GENETIC FACTORS IN KERATOCONUS

National Institutes of Health

Grant: 5R01DK116738-02

Genetic Etiology of Abdominal Hernia Susceptibility

National Institutes of Health

Grant: 3UL1TR001881-01S2

UCLA Clinical Translational Science Institute

National Institutes of Health

Grant: 5R01EY027004-04

The Role of Refractive Error in the Etiology of Glaucoma

Wellcome Trust

Grant: 203141

Human Genetics and Disease Biology: Core Renewal for the Wellcome Trust Centre for Human Genetics

National Institutes of Health

Grant: 5RC2AG036607-02

A Resource for Genetic Epidemiology Research in Adult Health and Aging

National Health and Medical Research Council (NHMRC)

Grant: 1116360

From discovery to therapy in genetic eye diseases

National Institutes of Health

Grant: 5U19HL069757-12

Pharmacogenomics and Risk of Cardiovascular Disease

National Health and Medical Research Council (NHMRC)

Grant: 1023911

Translation of genetic eye research integrating education, counselling and testing with gene discovery and gene based therapies for eye disease

Medical Research Council

Grant: MR/T040912/1

NIA NIH HHS

Grant: RC2 AG036607

NEI NIH HHS

Grant: R01 EY027004

NCATS NIH HHS

Grant: UL1 TR000124

NHLBI NIH HHS

Grant: HHSN268201200008C

NIDDK NIH HHS

Grant: R01 DK116738

NHLBI NIH HHS

Grant: U19 HL069757

NEI NIH HHS

Grant: R01 EY009052

NCATS NIH HHS

Grant: UL1 TR001881

NHLBI NIH HHS

Grant: HHSN268201200008I

Medical Research Council

Grant: MR/S031820/1

Wellcome Trust

Grant: 203141/Z/16/Z

Medical Research Council

Grant: G1002002

British Heart Foundation

Department of Health

Wellcome Trust

Influential Citations

goldLicense: cc-by

GOLDhttps://www.nature.com/articles/s42003-021-01784-0.pdf

publisherhttps://www.nature.com/articles/s42003-021-01784-0.pdf

publisherhttps://www.nature.com/articles/s42003-021-01784-0

repositoryhttps://kclpure.kcl.ac.uk/portal/en/publications/bfb10205-32e8-4f69-8592-172a51c9364c

repositoryhttps://pure.amsterdamumc.nl/files/139868762/A-multi-ethnic-genome-wide-association-study-implicates-collagen-matrix-integrity-and-cell-differentiation-pathways-in-k.pdf

Fields of Study

MedicineBiology0301 basic medicine03 medical and health sciences0303 health sciencesHumansAustraliaCase-Control StudiesCell DifferentiationCollagenEuropeExtracellular MatrixGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyKeratoconusPhenotypePolymorphism, Single NucleotideRisk AssessmentRisk Factors

MeSH Terms

HumansAustraliaCase-Control StudiesCell DifferentiationCollagenEuropeExtracellular MatrixGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyKeratoconusPhenotypePolymorphism, Single NucleotideRisk AssessmentRisk Factors

Keywords

Biomedical and clinical sciencesCorneal diseasesQH301-705.51.1 Normal biological development and functioningEMC OR-01610EyeKeratoconusGenome-wide association studiesPolymorphism, Single NucleotideRisk AssessmentArticleRare DiseasesRisk Factors616Genetics2.1 Biological and endogenous factorsHumansGenetic Predisposition to DiseasePolymorphismBiology (General)Eye Disease and Disorders of VisionOphthalmology and OptometryRadboudumc 12: Sensory disorders DCMN: Donders Center for Medical NeuroscienceHuman GenomeAustraliaCell DifferentiationSingle NucleotideBiological SciencesExtracellular MatrixEuropePhenotypeGenetic LociCase-Control StudiesWomen's HealthCollagenOphthalmology - Radboud University Medical CenterGenome-Wide Association Study

Sustainable Development Goals

SDG 3: 3. Good healthSDG 10: 10. No inequality