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Sex-specific single cell-level transcriptomic signatures of Rett syndrome disease progression

Communications Biology(2024)10.1038/s42003-024-06990-0Source: DataRank Database

Sex-specific single cell-level transcriptomic signatures of Rett syndrome disease progression is a research paper published in Communications Biology (2024). On theSindex it has a DataRank of 0.529. It has been cited 14 times, with 11 citing works in its 1-hop citation network.

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0.529DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access14 citations · 11 citing works in its network

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Data availability

Repositories this paper deposited data in (declared in PubMed).

BioProjectPRJNA1142998 PRJNA1157887

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (15 grants)OA: goldTopics (49)IDs (PubMed, PMC)Annotations (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 77%Citation Network 23%

Base Score Contribution

0.406

From this paper's citation signal

Citation Network Contribution

0.123

From 7 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 11 citers.

Single-dose administration of therapeutic divalent siRNA targeting MECP2 prevents lethality for one year in an MECP2 duplication mouse model
bioRxiv (Cold Spring Harbor Laboratory)20255 citations57 referencesContributes 0.031
Integrative analysis of 115 transcriptomic studies decodes the molecular landscape of neurodevelopmental disorders
Communications Biology20253 citations51 referencesContributes 0.027
Modulating alternative splicing of MECP2 is a potential therapeutic strategy for Rett syndrome
Science Translational Medicine20264 citations61 referencesContributes 0.026
Early transcriptional signatures of MeCP2 positive and negative cells in Rett syndrome
bioRxiv (Cold Spring Harbor Laboratory)20255 citations70 referencesContributes 0.026
Molecular Insights into Neurological Regression with a Focus on Rett Syndrome—A Narrative Review
International Journal of Molecular Sciences20258 citations116 referencesContributes 0.019

Authors (10)

Viktoria Haghani ORCID,Kari Neier ORCID,Keith J. Fraga ORCID,Ian Korf ORCID,Sophia M. Hakam

Live enrichment

PubMed:39384967 PMC:PMC11464704

U.S. Department of Health & Human Services | NIH | NIH Office of the Director (OD)

Grant: S10OD018223

NIAAA NIH HHS

Grant: R01 AA027075

NICHD NIH HHS

Grant: R01 HD112991

U.S. Department of Health & Human Services | NIH | NIH Office of the Director

Grant: S10OD010786

U.S. Department of Health & Human Services | NIH | NICHD | National Center for Medical Rehabilitation Research

Grant: P50 HD103526

NCI NIH HHS

Grant: P30 CA093373

U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences

Grant: P30 ES023513

National Institutes of Health

Grant: 5R01AA027075-03

Neuroimmune interactions in Rett syndrome

National Institutes of Health

Grant: 5P50HD103526-03

MIND Institute Intellectual and Developmental Disabilities Research Center

National Institutes of Health

Grant: 1R03HS013039-01

Violence &SCI: Understanding the Rehabilitation Context

National Institutes of Health

Grant: 5P30ES023513-05

UC Davis Environmental Health Sciences Core Center

National Institutes of Health

Grant: 1S10OD018223-01A1

UC Davis Shared Astrios Cell Sorter

National Institutes of Health

Grant: 3P30CA093373-07S2

Cancer Center Support Grant - P30

National Institutes of Health

Grant: 1S10OD010786-01

Acquisition of Covaris E220 and Sciclone G3 systems for high throughput sequencin

U.S. Department of Health & Human Services | NIH | NIH Office of the Director

goldLicense: CC BY

Europe_PMChttps://europepmc.org/articles/PMC11464704

Europe_PMChttps://europepmc.org/articles/PMC11464704?pdf=render

https://doi.org/10.1101/2024.05.16.594595

https://doi.org/10.1038/s42003-024-06990-0

https://pubmed.ncbi.nlm.nih.gov/38798575

Fields of Study

03 medical and health sciences0303 health sciences

MeSH Terms

AnimalsHumansMiceRett SyndromeDisease Models, AnimalDisease ProgressionMutationFemaleMaleMethyl-CpG-Binding Protein 2Single-Cell AnalysisTranscriptome

Keywords

MaleBiomedical and clinical sciencesQH301-705.5Methyl-CpG-Binding Protein 2Intellectual and Developmental Disabilities (IDD)1.1 Normal biological development and functioningBioinformatics and Computational Biology610NeurodegenerativeArticleMiceRare DiseasesGeneticsRett Syndrome2.1 Biological and endogenous factorsAnimalsHumansBiology (General)PediatricAnimalHuman GenomeNeurosciencesBiological SciencesBrain DisordersDisease Models, AnimalMental HealthNeurologicalDisease ModelsMutationDisease ProgressionWomen's HealthFemaleGeneric health relevanceSingle-Cell AnalysisTranscriptome