A multi-tissue human knee single-cell atlas identifies that osteoarthritis reduces regenerative tissue stem cells while increasing inflammatory pain macrophages is a dataset published in Communications Biology (2025). On theSindex it has a DataRank of 0.468, placing it in the top 40.6% of the data-sharing corpus. It has been cited 18 times, with 17 citing works in its 1-hop citation network. Its calibrated FAIR score is 38/100.
Ranks in the top 41% for downstream scientific impact
Linked data & code
DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?
FAIR checklist signals are shown for context only and do not affect DataRank scoring.
Full FAIR picture · advisory
The headline score is computed from the scored criteria — the fact-shaped checks (a repository, an accession, a licence) that two independent models agree on. The advisory criteria below are real FAIR guidance but rest on judgment calls that models read differently, so they inform without moving the number.
“The human knee OA single-cell RNA-seq data used in this study are publicly available under the following accession ID: cartilage (GSE220243, GSE169454, and GSE255460); meniscus (GSE220243); synovium and IPFP (GSE216651); and SCB (GSE196678).”— not found in the paper; verdict downgraded
GEO accession numbers (GSE series) are persistent identifiers in the repository scheme list. [downgraded to 'partial' — no verifiable quote from the paper] [majority verdict 'partial' (4/5 passes agreed)]
RDA-F1-01D — FAIR Data Maturity Model: 'Data is identified by a persistent identifier' (priorit · RDA-F1-02D — FAIR Data Maturity Model: 'Data is identified by a globally unique identifier' · FsF-F1-02D — F-UJI/FAIRsFAIR: 'Data is assigned a persistent identifier'
“samples of cartilage, meniscus, synovium & infrapatellar fat pad (SynoFP), and SCB from healthy individuals and OA patients were collected from the NCBI Gene Expression Omnibus (GEO) database”
The paper names NCBI GEO as the repository from which the data were collected and where they are publicly available. [majority verdict 'yes' (4/5 passes agreed)]
RDA-F4-01M — FAIR Data Maturity Model: metadata is offered so it can be harvested and indexed ( · NIH DMS Policy Element 4 (NOT-OD-21-014) — name the repository where data will be archived · NSTC Desirable Characteristics of Data Repositories (2022) — 'Long-Term Sustainability', 'Reten
“The human knee OA single-cell RNA-seq data used in this study are publicly available under the following accession ID: cartilage (GSE220243, GSE169454, and GSE255460); meniscus (GSE220243); synovium and IPFP (GSE216651); and SCB (GSE196678).”— not found in the paper; verdict downgraded
The dataset identifiers appear in the body text (Data availability section) but not as a reference-list entry. [downgraded to 'no' — no verifiable quote from the paper]
FORCE11 Joint Declaration of Data Citation Principles (2014) — data should be cited as a first- · RDA-F3-01M — metadata clearly and explicitly includes the identifier of the data it describes · FsF-F3-01M — F-UJI: 'Metadata includes the identifier of the data it describes'
Advisory · not in the published score
“The human knee OA single-cell RNA-seq data used in this study are publicly available under the following accession ID: cartilage (GSE220243, GSE169454, and GSE255460); meniscus (GSE220243); synovium and IPFP (GSE216651); and SCB (GSE196678).”— not found in the paper; verdict downgraded
The statement points to repository records with accession IDs, corresponding to Colavizza category 3. [downgraded to 'partial' — no verifiable quote from the paper]
Colavizza, Hrynaszkiewicz, Staden, Whitaker & McGillivray (2020), 'The citation advantage of li · Springer Nature research data policy — Data Availability Statements: standard statement templat · RDA-F3-01M — metadata clearly and explicitly includes the identifier of the data it describes
“The human knee OA single-cell RNA-seq data used in this study are publicly available under the following accession ID: cartilage (GSE220243, GSE169454, and GSE255460); meniscus (GSE220243); synovium and IPFP (GSE216651); and SCB (GSE196678).”— not found in the paper; verdict downgraded
The data availability statement provides an itemised list of datasets by tissue and accession, constituting an inventory of the data used. [downgraded to 'partial' — no verifiable quote from the paper] [majority verdict 'partial' (4/5 passes agreed)]
RDA-F2-01M — 'Rich metadata is provided to allow discovery' (priority Essential) · FsF-F2-01M — F-UJI: 'Metadata includes descriptive core elements to support data findability' · FsF-R1-01MD — F-UJI: 'Metadata specifies the content of the data'
“The human knee OA single-cell RNA-seq data used in this study are publicly available under the following accession ID: cartilage (GSE220243, GSE169454, and GSE255460); meniscus (GSE220243); synovium and IPFP (GSE216651); and SCB (GSE196678).”— not found in the paper; verdict downgraded
The route to the data is given with no stated precondition (publicly available in GEO). [downgraded to 'partial' — no verifiable quote from the paper]
RDA-A1.1-01D — 'Data is accessible through a free access protocol' · FsF-A1-01M — F-UJI: 'Metadata contains access level and access conditions of the data' · NSTC Desirable Characteristics of Data Repositories (2022) — 'Free and Easy Access'
Advisory · not in the published score
“The human knee OA single-cell RNA-seq data used in this study are publicly available under the following accession ID: cartilage (GSE220243, GSE169454, and GSE255460); meniscus (GSE220243); synovium and IPFP (GSE216651); and SCB (GSE196678).”— not found in the paper; verdict downgraded
The paper explicitly labels the data as 'publicly available', which is an access-level label from the standard vocabulary. [downgraded to 'partial' — no verifiable quote from the paper] [majority verdict 'partial' (3/5 passes agreed)]
FsF-A1-01M — F-UJI: 'Metadata contains access level and access conditions of the data' · RDA-A1-01M — metadata contains information to enable the user to get access to the data · COAR Controlled Vocabularies — Access Rights v1.0 (open / embargoed / restricted / metadata-onl
“The human knee OA single-cell RNA-seq data used in this study are publicly available under the following accession ID: cartilage (GSE220243, GSE169454, and GSE255460); meniscus (GSE220243); synovium and IPFP (GSE216651); and SCB (GSE196678).”— not found in the paper; verdict downgraded
The data are openly accessible from GEO with no named gatekeeper, so no institutional or personal gatekeeper is identified.
NIH Genomic Data Sharing Policy (NOT-OD-14-124) — controlled-access via a Data Access Committee · RDA-A1.2-01D — 'Data is accessible through an access protocol that supports authentication and · NIH DMS Policy Element 5 (NOT-OD-21-014) — Access, Distribution, or Reuse Considerations (conse
“The human knee OA single-cell RNA-seq data used in this study are publicly available under the following accession ID: cartilage (GSE220243, GSE169454, and GSE255460); meniscus (GSE220243); synovium and IPFP (GSE216651); and SCB (GSE196678).”— not found in the paper; verdict downgraded
The data are stated to be publicly available now, but no statement about how long they will persist (retention period) is given. [downgraded to 'no' — no verifiable quote from the paper]
NIH DMS Plan Element 4 (NOT-OD-21-014) — Data Preservation, Access, and Associated Timelines · NSTC Desirable Characteristics (2022), Organizational Infrastructure: 'Retention Policy' · RDA-A2-01M — 'Metadata is guaranteed to remain available after data is no longer available'
No file format is named for the released data.
FsF-R1.3-02D — F-UJI: 'Data is available in a file format recommended by the target research co · RDA-R1.3-02D — data is expressed in a machine-understandable community standard · RDA-I1-01D — data uses a knowledge representation expressed in a standardised format
Advisory · not in the published score
No community standard (e.g., MIAME, MINSEQE, ontology) is named for the data or metadata.
RDA-R1.3-01M — 'Metadata complies with a community standard' (priority Essential) · RDA-R1.3-01D — 'Data complies with a community standard' · RDA-I2-01M — '(Meta)data use vocabularies that follow FAIR principles'
“GSE220243, GSE169454, GSE255460, GSE216651, GSE196678”— not found in the paper; verdict downgraded
The paper gives GEO accession identifiers for the source datasets used in the study, which are resources other than the paper's own dataset. [downgraded to 'no' — no verifiable quote from the paper] [majority verdict 'no' (4/5 passes agreed)]
RDA-I3-01M — '(meta)data include references to other (meta)data' · RDA-I3-03M — 'metadata includes qualified references to other metadata' · FsF-I3-01M — F-UJI: 'Metadata includes links between the data and its related entities'
No licence is stated for the data; the article's CC-BY-NC-ND licence applies to the paper, not the data.
RDA-R1.1-01M — 'Metadata includes information about the licence under which the data can be reu · RDA-R1.1-02M — 'Metadata refers to a standard reuse licence' · RDA-R1.1-03M — 'Metadata refers to a machine-understandable reuse licence'
No version token or date is given for the data snapshot.
DataCite Metadata Schema 4.6 — the 'Version' property · RDA-R1.2-01M — provenance information (which version was used is provenance) · NSTC Desirable Characteristics of Data Repositories (2022) — 'Provenance', 'Retention Policy'
The paper does not mention code availability or provide a locator for the study's own code.
NIH DMS Policy Element 2 (NOT-OD-21-014) — 'Related Tools, Software and/or Code' · FAIR4RS Principles v1.0 (Chue Hong et al., 2022; RDA/FORCE11/ReSA) — FAIR Principles for Resear · FORCE11 Software Citation Principles (Smith, Katz & Niemeyer, 2016, PeerJ CS 2:e86)
“R01 DE031413”
Specific NIH grant numbers are provided in the Acknowledgements section.
DataCite Metadata Schema 4.6 — 'FundingReference' property (funderName, funderIdentifier, award · Crossref Funder Registry — canonical funder identifiers for funding metadata · RDA-F2-01M — rich metadata provided to allow discovery (funding is part of the descriptive reco
Advisory · not in the published score
“Seurat R package (v5.1.0)”
The paper names specific software packages and versions used for data processing, providing a provenance record. [majority verdict 'yes' (4/5 passes agreed)]
RDA-R1.2-01M — 'Metadata includes provenance information according to community- specific standa · FsF-R1.2-01M — F-UJI: 'Metadata includes provenance information about data creation or generati · W3C PROV-O (W3C Recommendation, 2013) — the entity/activity/agent model of provenance
No documentation object (README, codebook) is named as accompanying the data, and no variable-definition table is provided inside the article. [majority verdict 'no' (3/5 passes agreed)]
RDA-R1-01M — '(Meta)data are richly described with a plurality of accurate and relevant attribu · FsF-R1-01MD — F-UJI: 'Metadata specifies the content of the data' · NIH DMS Policy Element 3 (NOT-OD-21-014) — Standards (documentation and metadata to accompany t
Calibrated FAIR score — a parallel quality metric, independent of the DataRank citation score. See the full evaluation →
Base Score Contribution
0.442
From this paper's citation signal
Citation Network Contribution
0.0268
From 3 citing papers with measurable signal
Ranked by each citer's contribution to N(p) — log1p(Cq) divided by its reference count — out of 17 citers.
U.S. Department of Health & Human Services | NIH | National Institute of Dental and Craniofacial Research
Grant: R01 DE031413
National Institutes of Health
Grant: 1P30AR072571-01A1
Boston University CCCR
National Institutes of Health
Grant: 5R01DE031413-03
Mechanism of LSD1 Function and Its Therapeutic Application for Progressive Oral Malignancy
FWCI
18.64
Citation Percentile
1.0%
Citation Trend
Fields of Study
MeSH Terms
Keywords
Sustainable Development Goals