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Paracrine FGF21 dynamically modulates mTOR signaling to regulate thymus function across the lifespan

Nature Aging(2025)10.1038/s43587-024-00801-1Source: DataRank Database

Paracrine FGF21 dynamically modulates mTOR signaling to regulate thymus function across the lifespan is a research paper published in Nature Aging (2025). On theSindex it has a DataRank of 0.330. It has been cited 8 times.

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0.330DataRank · unranked

Scored on demand from live citation data

Open Access8 citations

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Linked data & code

geo gen arrayexpress omim uniprot doi

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (25 grants)Impact (FWCI 4.22)OA: greenTopics (64)IDs (PubMed, PMC, OpenAlex)Annotations (6)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.330

From this paper's citation signal

Citation Network Contribution

Citation network not refreshed for this result

This paper's DataRank is currently driven only by its base citation score. Citation network data was not refreshed for this result.

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Authors (12)

Neira Jones ORCID,Iwan G. A. Raza ORCID,Freedom M. Green ORCID,Yangming Xiao ORCID,Manpreet Kaur Semwal ORCID

Live enrichment

PubMed:39972173 PMC:PMC12003089 OpenAlex:https://openalex.org/W4407752554

U.S. Department of Health & Human Services | NIH | National Institute on Aging

Grant: R21AG081709

U.S. Department of Health & Human Services | NIH | National Institute on Aging

Grant: R01AG086271

U.S. Department of Health & Human Services | NIH | National Institute on Aging

Grant: T32AI138944

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Grant: R21AI154109R21

Swiss National Science Foundation

Grant: 171050

Transcriptional control and Epigenetic Mechanisms of Thymic Epithelial Cell Development and Function

Wellcome Trust

Grant: 105045/Z/14/Z

NIGMS NIH HHS

Grant: T32 GM145432

Swiss National Science Foundation

Grant: 310030

NIH HHS

Grant: S10 OD030432

Wellcome Trust

Grant: 211944/Z/18/Z

NIA NIH HHS

Grant: P30 AG013319

NCI NIH HHS

Grant: P30 CA054174

NIAID NIH HHS

Grant: R21 AI154109

National Institutes of Health

Grant: 5R21AG081709-02

The role of medullary thymic epithelial cell-derived growth factors in regulating thymus growth and atrophy

UK Research and Innovation

Grant: MR/S036407/1

The thymus stromal compartment across developmental stages: Determining single cell transcription, chromatin accessibility and spatial position

National Institutes of Health

Grant: 5R21AI154109-02

The role of paracrine mTOR signaling in regulating thymus size and function

National Institutes of Health

Grant: 5R01AG086271-02

The role of paracrine growth factor signaling in thymus function and age-associated dysfunction

National Institutes of Health

Grant: 5P30CA054174-16

SAN ANTONIO CANCER INSTITUTE

National Institutes of Health

Grant: 1S10OD030432-01A1

FACSAria Fusion cell sorter for Flow Cytometry Shared Resource

National Institutes of Health

Grant: 5T32AI138944-03

Graduate Research in Immunology Program (GRIP): To train graduate students for successful careers in academia, industry and government

Wellcome Trust

Grant: 105045

The Homunculus in our Thymus: A Cellular Genomics Approach .

Swiss National Science Foundation

Grant: 36407

Crystal chemistry of minerals

Wellcome Trust

Grant: 211944

Engineering a Functional Synthetic Thymus

Wellcome Trust

FWCI

4.22

Citation Percentile

0.9%

Citation Trend

2025

2026

greenLicense: Springer Nature TDM

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/12003089

publisherhttps://www.nature.com/articles/s43587-024-00801-1.pdf

publisherhttps://www.nature.com/articles/s43587-024-00801-1

journalhttps://doi.org/10.1038/s43587-024-00801-1

Fields of Study

Fibroblast Growth Factor ResearchPancreatic function and diabetesEpigenetics and DNA MethylationAnimalsThymus GlandTOR Serine-Threonine KinasesMiceFibroblast Growth FactorsSignal TransductionLongevityEpithelial CellsAgingParacrine CommunicationT-LymphocytesMice, Inbred C57BLMaleMechanistic Target of Rapamycin Complex 1FemaleMechanistic Target of Rapamycin Complex 2Gene Knock-In Techniques

MeSH Terms

Mechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2AgingAnimalsEpithelial CellsFemaleFibroblast Growth FactorsLongevityMaleMice, Inbred C57BLT-LymphocytesThymus GlandSignal TransductionParacrine CommunicationMiceGene Knock-In TechniquesTOR Serine-Threonine Kinases

Keywords

Paracrine signallingPI3K/AKT/mTOR pathwayCell biologyFGF21Function (biology)Signal transductionBiologyNeuroscienceFibroblast growth factorReceptorGeneticsMaleAgingTOR Serine-Threonine KinasesT-LymphocytesLongevityEpithelial CellsThymus GlandMechanistic Target of Rapamycin Complex 2Mechanistic Target of Rapamycin Complex 1Fibroblast Growth FactorsMice, Inbred C57BLMiceParacrine CommunicationAnimalsFemaleGene Knock-In Techniques

Sustainable Development Goals

SDG 0: Zero hunger

Paracrine FGF21 dynamically modulates mTOR signaling to regulate thymus function across the lifespan

FAIR Checklist

DataRank Breakdown

Authors (12)

Funding (25 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)