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Discovery of new pyrimidine-5-carbonitrile derivatives as anticancer agents targeting EGFR WT and EGFR T790M

Organic & Biomolecular Chemistry(2020)10.1039/d0ob01557aSource: DataRank Database

Discovery of new pyrimidine-5-carbonitrile derivatives as anticancer agents targeting EGFR WT and EGFR T790M is a research paper published in Organic & Biomolecular Chemistry (2020). On theSindex it has a DataRank of 0. It has been cited 120 times.

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0DataRank · unranked

Scored on demand from live citation data

120 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (3 grants)Impact (FWCI 8.56)OA: closedTopics (44)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (0/2)

Interoperable (0/2)

Reusable (0/3)

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Authors (13)

Ibrahim H. Eissa ORCID,Mohamed R. Oun,Mohamed Ayman El‐Zahabi ORCID,Mohammed S. Taghour ORCID,Amany Belal ORCID

Live enrichment

PubMed:32959865 OpenAlex:https://openalex.org/W3085080249

NIGMS NIH HHS

Grant: P41 GM122698

NIBIB NIH HHS

Grant: R01 EB009772

NIH HHS

Grant: S10 OD028753

FWCI

8.56

Citation Percentile

1.0%

Citation Trend

2020

2021

2022

2023

2024

2025

2026

closedLicense: http://rsc.li/journals-terms-of-use

publisherhttp://pubs.rsc.org/en/content/articlepdf/2020/OB/D0OB01557A

journalhttps://doi.org/10.1039/d0ob01557a

repositoryhttps://pubmed.ncbi.nlm.nih.gov/32959865

Fields of Study

Lung Cancer Treatments and MutationsPI3K/AKT/mTOR signaling in cancerSynthesis and biological activity

MeSH Terms

Antineoplastic AgentsDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansNitrilesPyrimidinesStructure-Activity RelationshipMolecular StructureApoptosisCell Line, TumorProtein Kinase InhibitorsCell ProliferationDrug DiscoveryMolecular Docking SimulationErbB Receptors

Keywords

ChemistryT790MErlotinibApoptosisGefitinibEGFR inhibitorsEpidermal growth factor receptorCell cycle checkpointCytotoxic T cellA549 cellTyrosine kinaseCell cultureCell cycleKinaseCancer researchCytotoxicityCell growthCancer cellIC50In vitroCancerBiochemistryReceptorBiologyInternal medicineMedicine

Sustainable Development Goals

SDG 0: Good health and well-being

Discovery of new pyrimidine-5-carbonitrile derivatives as anticancer agents targeting EGFR WT and EGFR T790M

FAIR Checklist

Authors (13)

Funding (3 grants)

Impact

Open Access

Topics