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Target 2035 – update on the quest for a probe for every protein

RSC Medicinal Chemistry(2022)10.1039/d1md00228gSource: DataRank Database

Target 2035 – update on the quest for a probe for every protein is a research paper published in RSC Medicinal Chemistry (2022). On theSindex it has a DataRank of 1.7. It has been cited 83 times, with 46 citing works in its 1-hop citation network.

N/A

1.7DataRank · unranked

Scored on demand from live citation data

83 citations · 46 citing works in its network

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doi

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (19 grants)OA: hybridTopics (25)IDs (PubMed, PMC)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (0/2)

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 40%Citation Network 60%

Base Score Contribution

0.665

From this paper's citation signal

Citation Network Contribution

0.986

From 32 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 46 citers.

A conversation on using chemical probes to study protein function in cells and organisms
Nature Communications20229 citations17 referencesContributes 0.135
PROTAC technology: A new drug design for chemical biology with many challenges in drug discovery
Drug Discovery Today2022150 citations75 referencesContributes 0.067
In silico screening of LRRK2 WDR domain inhibitors using deep docking and free energy simulations
Chemical Science202426 citations55 referencesContributes 0.060
Generic protein–ligand interaction scoring by integrating physical prior knowledge and data augmentation modelling
Nature Machine Intelligence202455 citations70 referencesContributes 0.058
BAY-069, a Novel (Trifluoromethyl)pyrimidinedione-Based BCAT1/2 Inhibitor and Chemical Probe
Journal of Medicinal Chemistry202225 citations60 referencesContributes 0.054

Authors (63)

Suzanne Ackloo ORCID,Arij Al Chawaf,Bissan Al-Lazikani,Albert Antolin,Jonathan B. Baell ORCID

Live enrichment

PubMed:35211674 PMC:PMC8792830

Cancer Research UK

Grant: C35696/A23187

Genome Canada

Grant: OGI-196

Wellcome Trust

Grant: 204735/Z/16/Z

Wellcome Trust

Grant: 212969/Z/18/Z

Seventh Framework Programme

Grant: 600388

ACC10 programme to foster mobility of researchers with a focus in applied research and technology transfer

National Cancer Institute

Grant: T32 CA236754

Wellcome Trust

Grant: 106169/Z/14/Z

Cancer Research UK

Grant: 22897

Innovative Medicines Initiative

Grant: 875510

EUbOPEN: Enabling and Unlocking biology in the OPEN

Cancer Research UK

Grant: C309/A11566

European Commission

Grant: 115766

Unrestricted Leveraging of Targets for Research Advancement and Drug Discovery

Wellcome Trust

Grant: 204735

Harnessing polypharmacology in precision oncology

National Institutes of Health

Grant: 5T32CA236754-02

Cancer Chemical Biology and Metabolism Training Program

Wellcome Trust

Grant: unidentified

unidentified

Wellcome Trust

Grant: 212969

The Chemical Probes Portal: An Open Resource Empowering High Quality Chemical Biology

European Molecular Biology Laboratory

Mark Foundation For Cancer Research

Agència per a la Competitivitat de l'Empresa

Chordoma Foundation

hybridLicense: cc-by

publisherhttps://pubs.rsc.org/en/content/articlepdf/2022/md/d1md00228g

repositoryhttps://discovery.dundee.ac.uk/en/publications/617b4c3a-a525-48fe-8932-e4f972a8c479

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8792830

Europe_PMChttps://europepmc.org/articles/PMC8792830

Europe_PMChttps://europepmc.org/articles/PMC8792830?pdf=render

Fields of Study

0301 basic medicine03 medical and health sciences0303 health sciences

Keywords

/dk/atira/pure/subjectarea/asjc/1300/1313Biochemistry & Molecular Biology610name=PharmacologyMedicinal576name=Molecular MedicinePharmacology & Pharmacyname=Pharmaceutical Science/dk/atira/pure/subjectarea/asjc/1300/1303020Science & Technology/dk/atira/pure/subjectarea/asjc/1600/1605/dk/atira/pure/subjectarea/asjc/3000/3004name=BiochemistryDRUG DISCOVERYChemistryname=Organic Chemistry/dk/atira/pure/subjectarea/asjc/3000/3002/dk/atira/pure/subjectarea/asjc/3000/3003name=Drug DiscoveryLife Sciences & Biomedicine

Sustainable Development Goals

SDG 3: 3. Good health