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Activating mutations drive human MEK1 kinase using a gear-shifting mechanism

Biochemical Journal(2023)10.1042/bcj20230281Source: DataRank Database

Activating mutations drive human MEK1 kinase using a gear-shifting mechanism is a research paper published in Biochemical Journal (2023). On theSindex it has a DataRank of 0. It has been cited 3 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access3 citations

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pdb doi

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (6 grants)Impact (FWCI 0.40)OA: hybridTopics (29)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (5)

Yiming Wang ORCID,Zhangtao Chen,Krishna Suresh ORCID,Ravi Radhakrishnan ORCID,Keshav Patil ORCID

Live enrichment

PubMed:37869794 PMC:PMC10872882 OpenAlex:https://openalex.org/W4387866351

HHS | NIH | National Cancer Institute

Grant: CA227550

HHS | NIH | National Cancer Institute

Grant: CA244660

HHS | NIH | National Cancer Institute

Grant: CA250044

NCI NIH HHS

Grant: U01 CA250044

NCI NIH HHS

Grant: R01 CA244660

NCI NIH HHS

Grant: U01 CA227550

FWCI

0.40

Citation Percentile

0.7%

Citation Trend

2024

2025

hybridLicense: cc-by

journalhttps://portlandpress.com/biochemj/article-pdf/doi/10.1042/BCJ20230281/951004/bcj-2023-0281.pdf

publisherhttps://portlandpress.com/biochemj/article-pdf/doi/10.1042/BCJ20230281/951004/bcj-2023-0281.pdf

publisherhttps://portlandpress.com/biochemj/article-pdf/480/21/1733/951588/bcj-2023-0281.pdf

journalhttps://doi.org/10.1042/bcj20230281

repositoryhttps://pubmed.ncbi.nlm.nih.gov/37869794

Fields of Study

Melanoma and MAPK PathwaysProtein Structure and DynamicsHeat shock proteins research

MeSH Terms

Gain of Function MutationHumansMutationNeoplasms

Keywords

Protein kinase AKinaseMechanism (biology)BiologyEnergy landscapeMutationFunction (biology)Computational biologyMutantCell biologyMAP3K7MAP kinase kinase kinaseBiophysicsGeneticsBiochemistryGenePhysicsEnhanced SamplingOncogenic DriverConformational PlasticityActivating MutationsDynamical Correlation

Sustainable Development Goals

SDG 0: Affordable and clean energy

Activating mutations drive human MEK1 kinase using a gear-shifting mechanism

FAIR Checklist

Authors (5)

Funding (6 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)