Expression of the Vax family homeobox genes suggests multiple roles in eye development is a research paper published in Genes to Cells (1999). On theSindex it has a DataRank of 3.3. It has been cited 57 times, with 54 citing works in its 1-hop citation network.
BackgroundHomeobox gene products are thought to regulate target genes involved in the regional specification of tissues and organs. Several genes play roles in eye development.ResultsWe isolated two new mouse homeobox genes, Vax1 and Vax2, expressed in retina primordium. The two genes share the same gene organization, consisting of three exons with predicted amino acid sequences identical in the homeodomain but diversified in other regions. At 9.5 days post coitum, both Vax genes were expressed in optic vesicles. At 11.5–14.5 dpc, Vax1 became restricted to the optic stalk, while Vax2 was expressed in the ventral half of the neural retina. Mapping of Vax2 between D6Mit3 and D6Mit8 on chromosome 6 indicated a possible linkage with Emx1.ConclusionsThe expression patterns of Vax genes suggest separate and specific involvement in eye development. Vax1 may contribute to differentiation of the neuroretina, pigmented epithelium and optic stalk, while Vax2 could function in the establishment of the dorso‐ventral axis of the retina and the visual system. The chromosomal location of Vax2 suggests that Vax2‐Emx1 and Vax1‐Emx2 arose by chromosome duplication of the same ancestral gene.
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Base Score Contribution
0.609
From this paper's citation signal
Citation Network Contribution
2.7
From 50 citing papers with measurable signal
Ranked by citation count — the same ordering the engine uses when summing log1p(Cq) over citers.
DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 18% comes from its base citations and 82% from the citation network (50 citing papers contributed measurable signal).
Citers are pulled from OpenAlex sorted by cited_by_count:descand capped per paper, so when the cap binds we keep the highest-signal references and the score is reproducible across reruns.
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