<b>Regulation of the ecdysone receptor, USP, E75 and MHR3 mRNAs by 20‐hydroxyecdysone in the GV1 cell line of the tobacco hornworm,</b> <b> <i>Manduca sexta</i> </b> is a research paper published in Insect Molecular Biology (1997). On theSindex it has a DataRank of 1.9. It has been cited 38 times, with 29 citing works in its 1-hop citation network.
The responsiveness of several nuclear transcription factor genes to 20‐hydroxyecdysone (20E) was characterized in an embryonic cell line, GV1, from Manduca sexta . The mRNA for the Manduca ecdysone receptor ( Ms EcR) was present in the GV1 cells and transiently increased 2.3‐fold by 5 h after the addition of 2 μg/ml (4 × 10 −6 M ) 20‐hydroxyecdysone (20E). In contrast, Manduca ultraspiracle ( Ms USP) mRNA level in the GV1 cells decreased slowly to half of its initial level by 12 h when exposed to the same concentration of 20E. The mRNAs for two putative transcription factors, Ms E75 and MHR3, were induced in the GV1 cells by 20E, with that for E75 appearing within 1 h whereas that for MHR3 within 2 h. The ED 50 s for induction of MsE75 and MHR3 gene expression in GV1 cells were 1.2 × 10 −6 and 2.5 × 10 −6 M 20E, respectively.
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Base Score Contribution
0.550
From this paper's citation signal
Citation Network Contribution
1.4
From 28 citing papers with measurable signal
Ranked by citation count — the same ordering the engine uses when summing log1p(Cq) over citers.
DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 29% comes from its base citations and 71% from the citation network (28 citing papers contributed measurable signal).
Citers are pulled from OpenAlex sorted by cited_by_count:descand capped per paper, so when the cap binds we keep the highest-signal references and the score is reproducible across reruns.
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