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Clostridioides difficile Toxin A Remodels Membranes and Mediates DNA Entry Into Cells to Activate Toll-Like Receptor 9 Signaling

Gastroenterology(2020)10.1053/j.gastro.2020.08.038Source: DataRank Database

Clostridioides difficile Toxin A Remodels Membranes and Mediates DNA Entry Into Cells to Activate Toll-Like Receptor 9 Signaling is a research paper published in Gastroenterology (2020). On theSindex it has a DataRank of 0.442. It has been cited 18 times.

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0.442DataRank · unranked

Scored on demand from live citation data

Open Access18 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (13 grants)Impact (FWCI 0.22)OA: greenTopics (79)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.442

From this paper's citation signal

Citation Network Contribution

Citation network not refreshed for this result

This paper's DataRank is currently driven only by its base citation score. Citation network data was not refreshed for this result.

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Authors (15)

Xiaotong Yang,Jaime de Anda ORCID,Jun Huang ORCID,Dan Li ORCID,Hua Xu ORCID

Live enrichment

PubMed:32841647 OpenAlex:https://openalex.org/W3081131393

National Institute of Allergy and Infectious Diseases

Grant: RO1 AI095256

National Institute of Allergy and Infectious Diseases

Grant: RO1 AI052453

National Institute of Allergy and Infectious Diseases

Grant: RO1 AI143730

National Institute of Allergy and Infectious Diseases

Grant: RO1 AI116596

Basic Energy Sciences

Grant: DE-AC02-76SF00515

National Institute of General Medical Sciences

Grant: P41GM103393

National Science Foundation

Grant: DMR1808459

National Science Foundation

Grant: DGE-1650604

National Institutes of Health

Grant: 8P41GM103393-33

A Synchroton Radiation Structural Biology Resource

National Institutes of Health

Grant: 5R01AI116596-03

Ultrasensitive C.difficile toxin measurement for diagnosis and outcome prediction

National Institutes of Health

Grant: 5R01AI143730-05

Surface sensing, memory, and motility control in biofilm formation

National Science Foundation

Grant: 1808459

Programming innate immune responses using glycomimetic macromolecular complexes

National Institutes of Health

Grant: 1R01AI095256-01A1

Combination Clostridium Difficile Toxin and Adhesin Vaccine

FWCI

0.22

Citation Percentile

0.7%

Citation Trend

2021

2022

2023

2024

2025

2026

greenLicense: Elsevier TDM

repositoryhttps://www.osti.gov/biblio/1844371

publisherhttps://api.elsevier.com/content/article/PII:S0016508520351088?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0016508520351088?httpAccept=text/plain

journalhttps://doi.org/10.1053/j.gastro.2020.08.038

Fields of Study

Clostridium difficile and Clostridium perfringens researchYersinia bacterium, plague, ectoparasites researchEscherichia coli research studies0301 basic medicine03 medical and health sciences0303 health sciences

MeSH Terms

Gastrointestinal MicrobiomeAnimalsAnti-Bacterial AgentsBacterial ToxinsClostridium InfectionsColitisDisease Models, AnimalDNA, BacterialEnterotoxinsFemaleHumansImmunity, InnateSignal TransductionClostridioides difficileMice, KnockoutMolecular ChaperonesToll-Like Receptor 9Mice

Keywords

TLR9Toll-Like Receptor 9Innate immune systemBiologyToll-like receptorReceptorCell biologyClostridium difficile toxin AMolecular biologyImmune systemMicrobiologyChemistryImmunologyGeneBiochemistryGene expressionDNA, BacterialAntibiotic-Associated Diarrhea and Colitis1.1 Normal biological development and functioningKnockoutClinical SciencesBacterial Toxins610Paediatrics and Reproductive MedicineEnterotoxinsMiceInnateAnimalsHumansMice, KnockoutBiomedical and Clinical SciencesGastroenterology & HepatologyAnimalClostridioides difficileBacterialImmunityNeurosciencesDNASAXSColitisPore FormationImmunity, InnateAnti-Bacterial AgentsGastrointestinal MicrobiomeNutrition and dieteticsDisease Models, AnimalInfectious DiseasesEmerging Infectious DiseasesDisease ModelsClostridium InfectionsFemaleDigestive DiseasesIntestinal InflammationMolecular ChaperonesSignal Transduction

Sustainable Development Goals

SDG 3: 3. Good health