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Zinc-Dependent Regulation of ZEB1 and YAP1 Coactivation Promotes Epithelial-Mesenchymal Transition Plasticity and Metastasis in Pancreatic Cancer

Gastroenterology(2021)10.1053/j.gastro.2020.12.077Source: DataRank Database

Zinc-Dependent Regulation of ZEB1 and YAP1 Coactivation Promotes Epithelial-Mesenchymal Transition Plasticity and Metastasis in Pancreatic Cancer is a research paper published in Gastroenterology (2021). On theSindex it has a DataRank of 5.2. It has been cited 215 times, with 188 citing works in its 1-hop citation network.

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5.2DataRank · unranked

Scored on demand from live citation data

Open Access215 citations · 188 citing works in its network

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Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (12 grants)OA: greenTopics (80)Linked Datasets (22)DataCite Reuse (22)IDs (PubMed, PMC)Annotations (1)

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Context only (not used in score)

Findable (2/2)

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Accessible (1/2)

Open Access

Interoperable (2/2)

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Reusable (0/3)

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DataRank Breakdown

Base Score 15%Citation Network 85%

Base Score Contribution

0.806

From this paper's citation signal

Citation Network Contribution

4.4

From 144 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 188 citers.

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Authors (15)

Yuqing Zhang ORCID,Jingxuan Yang ORCID,Hanxiang Zhan ORCID,Zhijun Zhou ORCID,Yuanyuan Jiang ORCID

Live enrichment

PubMed:33421513 PMC:PMC8035249

National Cancer Institute

Grant: P30CA225520

National Institutes of Health

Grant: R01 CA186338-01A1

National Institutes of Health

Grant: R01 CA203108

National Institutes of Health

Grant: R01 CA247234-01

NCI NIH HHS

Grant: R01 CA186338

NCI NIH HHS

Grant: R01 CA247234

NCI NIH HHS

Grant: R01 CA136526

National Institutes of Health

Grant: 5R01CA247234-04

Role of Zinc Dependent EMT-Transcription Factors (EMT-TF) in Pancreatic Cancer Metastasis

National Institutes of Health

Grant: 7R01CA186338-02

ZIP4 is a Novel Molecular Target in Human Pancreatic Cancer

National Institutes of Health

Grant: 3P30CA225520-06S4

Stephenson Cancer Center - Cancer Center Support Grant

National Institutes of Health

Grant: 5R01CA203108-04

Prognostic Biomarkers for ZIP4-mediated Cachexia in Pancreatic Cancer

William and Ella Owens Medical Research Foundation

greenLicense: Elsevier TDM

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8035249

publisherhttps://api.elsevier.com/content/article/PII:S0016508521000251?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0016508521000251?httpAccept=text/plain

repositoryhttps://orbi.uliege.be/handle/2268/330823

https://doi.org/10.1053/j.gastro.2020.12.077

Fields of Study

0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

Cell Line, TumorSpheroids, CellularAnimalsHumansMicePancreatic NeoplasmsNeoplasm InvasivenessNeoplasm MetastasisZincAdaptor Proteins, Signal TransducingCation Transport ProteinsIntegrin alpha3Transcription FactorsMicroRNAsSignal TransductionCell MovementGene Expression Regulation, NeoplasticEpithelial-Mesenchymal TransitionCell PlasticityZinc Finger E-box-Binding Homeobox 1YAP-Signaling Proteins

Keywords

Posttranscriptional RegulationZinc HomeostasisTranscription CoactivationITGA3 protein, humanPancreatic Neoplasms/pathologyIntegrin alpha3Cell PlasticityIntegrin alpha3/metabolismAdaptor Proteins, Signal Transducing/geneticsMiceCell MovementZEB1 protein, mouseNeoplasm MetastasisMIRN373 microRNA, humanCation Transport ProteinsPancreatic Neoplasms/metabolismGastroenterologyCation Transport Proteins/metabolismLife sciencesZinc/metabolismGene Expression Regulation, NeoplasticItga3 protein, mouseZincZinc Finger E-box-Binding Homeobox 1/metabolismSciences du vivantYap1 protein, mouseSignal TransductionEpithelial-Mesenchymal TransitionYAP1 protein, humanTranscription Factors/geneticsBiochimie, biophysique & biologie moléculaireIntegrin alpha3/geneticsCell Line, TumorSpheroids, CellularSLC39A4 protein, humanMicroRNAs/metabolismAnimalsHumansTranscription Factors/metabolismNeoplasm InvasivenessZEB1 protein, humanAdaptor Proteins, Signal TransducingMIRN373 microRNA, mouseHepatologyCation Transport Proteins/geneticsZinc Finger E-box-Binding Homeobox 1Slc39a4 protein, mouseYAP-Signaling ProteinsPancreatic Neoplasms/geneticsPancreatic NeoplasmsMicroRNAs/geneticsMicroRNAsAdaptor Proteins, Signal Transducing/metabolismZinc Finger E-box-Binding Homeobox 1/geneticsBiochemistry, biophysics & molecular biologyTranscription Factors

Additional file 1 of Functional interaction between endothelin-1 and ZEB1/YAP signaling regulates cellular plasticity and metastasis in high-grade serous ovarian cancer

10.6084/m9.figshare.19670270.v1figshare

Additional file 1 of Functional interaction between endothelin-1 and ZEB1/YAP signaling regulates cellular plasticity and metastasis in high-grade serous ovarian cancer

10.6084/m9.figshare.19670270figshare

Additional file 2 of Functional interaction between endothelin-1 and ZEB1/YAP signaling regulates cellular plasticity and metastasis in high-grade serous ovarian cancer

10.6084/m9.figshare.19670273.v1figshare

Additional file 2 of Functional interaction between endothelin-1 and ZEB1/YAP signaling regulates cellular plasticity and metastasis in high-grade serous ovarian cancer

10.6084/m9.figshare.19670273figshare

Additional file 3 of Functional interaction between endothelin-1 and ZEB1/YAP signaling regulates cellular plasticity and metastasis in high-grade serous ovarian cancer

10.6084/m9.figshare.19670276.v1figshare

Additional file 3 of Functional interaction between endothelin-1 and ZEB1/YAP signaling regulates cellular plasticity and metastasis in high-grade serous ovarian cancer

10.6084/m9.figshare.19670276figshare

Additional file 4 of Functional interaction between endothelin-1 and ZEB1/YAP signaling regulates cellular plasticity and metastasis in high-grade serous ovarian cancer

10.6084/m9.figshare.19670279.v1figshare

Additional file 4 of Functional interaction between endothelin-1 and ZEB1/YAP signaling regulates cellular plasticity and metastasis in high-grade serous ovarian cancer

10.6084/m9.figshare.19670279figshare

Additional file 1 of The PRMT5-LSD1 axis confers Slug dual transcriptional activities and promotes breast cancer progression

10.6084/m9.figshare.19980456.v1figshare

Additional file 1 of The PRMT5-LSD1 axis confers Slug dual transcriptional activities and promotes breast cancer progression

10.6084/m9.figshare.19980456figshare

Additional file 2 of CXCL12/CXCR7/β-arrestin1 biased signal promotes epithelial-to-mesenchymal transition of colorectal cancer by repressing miRNAs through YAP1 nuclear translocation

10.6084/m9.figshare.21303721.v1figshare

Additional file 2 of CXCL12/CXCR7/β-arrestin1 biased signal promotes epithelial-to-mesenchymal transition of colorectal cancer by repressing miRNAs through YAP1 nuclear translocation

10.6084/m9.figshare.21303721figshare

Additional file 1 of lncRNA FGD5-AS1 is required for gastric cancer proliferation by inhibiting cell senescence and ROS production via stabilizing YBX1

10.6084/m9.figshare.26182218.v1figshare

Additional file 1 of lncRNA FGD5-AS1 is required for gastric cancer proliferation by inhibiting cell senescence and ROS production via stabilizing YBX1

10.6084/m9.figshare.26182218figshare

Additional file 1 of LINC00543 promotes colorectal cancer metastasis by driving EMT and inducing the M2 polarization of tumor associated macrophages

10.6084/m9.figshare.26571433.v1figshare

Additional file 1 of LINC00543 promotes colorectal cancer metastasis by driving EMT and inducing the M2 polarization of tumor associated macrophages

10.6084/m9.figshare.26571433figshare

Additional file 1 of Human pancreatic cancer patients with Epithelial-to-Mesenchymal Transition and an aggressive phenotype show a disturbed balance in Protein Phosphatase Type 2A expression and functionality

10.6084/m9.figshare.26588817.v1figshare

10.6084/m9.figshare.26588817figshare

Additional file 1 of CCDC25 suppresses clear cell renal cell carcinoma progression by LATS1/YAP-mediated regulation of the hippo pathway

10.6084/m9.figshare.26701654.v1figshare

Additional file 1 of CCDC25 suppresses clear cell renal cell carcinoma progression by LATS1/YAP-mediated regulation of the hippo pathway

10.6084/m9.figshare.26701654figshare