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Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression

Gastroenterology(2021)10.1053/j.gastro.2021.06.045Source: DataRank Database

Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression is a research paper published in Gastroenterology (2021). On theSindex it has a DataRank of 2.8. It has been cited 124 times, with 108 citing works in its 1-hop citation network.

N/A

2.8DataRank · unranked

Scored on demand from live citation data

Open Access124 citations · 108 citing works in its network

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Linked data & code

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DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (12 grants)Impact (FWCI 8.80)OA: hybridTopics (71)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 26%Citation Network 74%

Base Score Contribution

0.724

From this paper's citation signal

Citation Network Contribution

2.1

From 90 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 108 citers.

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Journal of Hepatology2022196 citations51 referencesContributes 0.104
SIRT5’s GOT1 up on PDAC
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Single-cell and spatial analyses revealed the co-location of cancer stem cells and SPP1+ macrophage in hypoxic region that determines the poor prognosis in hepatocellular carcinoma
npj Precision Oncology202490 citations59 referencesContributes 0.076

Authors (31)

Surendra K. Shukla ORCID,Enza Vernucci ORCID,Chunbo He ORCID,Dezhen Wang ORCID,Ryan J. King ORCID

Live enrichment

PubMed:34245764 PMC:PMC8546779 OpenAlex:https://openalex.org/W3179794872

National Cancer Institute

Grant: R01CA210439

National Cancer Institute

Grant: R01 CA216853

National Cancer Institute

Grant: R01CA163649

National Cancer Institute

Grant: 2P50 CA127297

National Institutes of Health

Grant: P01 CA2117798

Associazione Italiana per la Ricerca sul Cancro

Grant: P30 CA036727

Associazione Italiana per la Ricerca sul Cancro

Grant: 19162

NCI NIH HHS

Grant: P01 CA217798

NCI NIH HHS

Grant: U01 CA210240

NCI NIH HHS

Grant: P50 CA127297

NCI NIH HHS

Grant: T32 CA009476

China Scholarship Council

FWCI

8.80

Citation Percentile

1.0%

Citation Trend

2021

2022

2023

2024

2025

2026

hybridLicense: cc-by-nc-nd

journalhttp://www.gastrojournal.org/article/S0016508521031590/pdf

publisherhttp://www.gastrojournal.org/article/S0016508521031590/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0016508521031590?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0016508521031590?httpAccept=text/plain

journalhttps://doi.org/10.1053/j.gastro.2021.06.045

Fields of Study

Sirtuins and Resveratrol in MedicinePARP inhibition in cancer therapyProtein Degradation and InhibitorsAnimalsAntineoplastic Combined Chemotherapy ProtocolsAspartate Aminotransferase, CytoplasmicCarcinoma, Pancreatic DuctalCell Line, TumorDeoxycytidineDisease ProgressionEnergy MetabolismEnzyme ActivationEnzyme ActivatorsFemaleGene Expression Regulation, NeoplasticHumansMaleMice, Inbred C57BLMice, Inbred NODMice, KnockoutMice, SCIDMutationPancreatic NeoplasmsProto-Oncogene Proteins p21(ras)Signal TransductionSirtuinsTumor BurdenTumor Cells, CulturedXenograft Model Antitumor AssaysGemcitabineMice

MeSH Terms

GemcitabineAnimalsAntineoplastic Combined Chemotherapy ProtocolsDeoxycytidineEnergy MetabolismEnzyme ActivationFemaleHumansMaleMice, Inbred C57BLMutationPancreatic NeoplasmsTumor Cells, CulturedSignal TransductionGene Expression Regulation, NeoplasticProto-Oncogene Proteins p21(ras)Mice, SCIDMice, Inbred NODMice, KnockoutDisease ProgressionEnzyme ActivatorsCarcinoma, Pancreatic DuctalXenograft Model Antitumor AssaysAspartate Aminotransferase, CytoplasmicSirtuinsCell Line, TumorTumor BurdenMice

Keywords

KRASPancreatic cancerCancer researchMedicineCancerChemistryInternal medicineColorectal cancerSirt5Glutamine MetabolismGlutathione MetabolismGot1

Sustainable Development Goals

SDG 0: No poverty