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Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

Proceedings of the National Academy of Sciences(2008)10.1073/pnas.0806268105Source: DataRank Database

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy is a research paper published in Proceedings of the National Academy of Sciences (2008). On theSindex it has a DataRank of 0.987. It has been cited 718 times.

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0.987DataRank · unranked

Scored on demand from live citation data

Open Access718 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Impact (FWCI 9.88)OA: greenTopics (55)Linked Datasets (8)DataCite Reuse (8)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

DataCite relations
Linked datasets

Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.987

From this paper's citation signal

Citation Network Contribution

Citation network not refreshed for this result

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Authors (9)

Tsutomu Ohta,Kit I. Tong,Akiko Kokubu,Reiko Odogawa,Koji Tsuta

Live enrichment

PubMed:18757741 PMC:PMC2533230 OpenAlex:https://openalex.org/W1998560601

FWCI

9.88

Citation Percentile

1.0%

Citation Trend

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repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/2533230

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.0806268105

journalhttps://doi.org/10.1073/pnas.0806268105

repositoryhttps://pubmed.ncbi.nlm.nih.gov/18757741

Fields of Study

Genomics, phytochemicals, and oxidative stressGlutathione Transferases and PolymorphismsActive Transport, Cell NucleusAntineoplastic AgentsBase SequenceCell Line, TumorCullin ProteinsDown-RegulationGene Expression Regulation, NeoplasticHumansIntracellular Signaling Peptides and ProteinsKelch-Like ECH-Associated Protein 1Models, MolecularMutationNF-E2-Related Factor 2NeoplasmsOxidative StressProtein BindingProtein Structure, TertiarySubstrate SpecificityTranscription, Genetic

MeSH Terms

Kelch-Like ECH-Associated Protein 1Antineoplastic AgentsBase SequenceHumansModels, MolecularMutationNeoplasmsProtein BindingSubstrate SpecificityTranscription, GeneticDown-RegulationGene Expression Regulation, NeoplasticProtein Structure, TertiaryOxidative StressActive Transport, Cell NucleusCullin ProteinsCell Line, TumorIntracellular Signaling Peptides and ProteinsNF-E2-Related Factor 2

Keywords

KEAP1Ubiquitin ligaseUbiquitinCancer researchGene knockdownCancer cellBiologyCell biologyDNA ligaseCancerChemistryGeneBiochemistryGeneticsTranscription factor

Sustainable Development Goals

SDG 0: Good health and well-being

Additional file 1 of Nrf2 promotes esophageal squamous cell carcinoma (ESCC) resistance to radiotherapy through the CaMKIIα-associated activation of autophagy

10.6084/m9.figshare.12744138.v1figshare

Additional file 1 of Nrf2 promotes esophageal squamous cell carcinoma (ESCC) resistance to radiotherapy through the CaMKIIα-associated activation of autophagy

10.6084/m9.figshare.12744138figshare

Additional file 10 of Systematic interrogation of mutation groupings reveals divergent downstream expression programs within key cancer genes

10.6084/m9.figshare.14551616.v1figshare

Additional file 10 of Systematic interrogation of mutation groupings reveals divergent downstream expression programs within key cancer genes

10.6084/m9.figshare.14551616figshare

Additional file 2 of SLC7A11 regulated by NRF2 modulates esophageal squamous cell carcinoma radiosensitivity by inhibiting ferroptosis

10.6084/m9.figshare.16456893.v1figshare

Additional file 1 of SLC7A11 regulated by NRF2 modulates esophageal squamous cell carcinoma radiosensitivity by inhibiting ferroptosis

10.6084/m9.figshare.16456890figshare

Additional file 1 of SLC7A11 regulated by NRF2 modulates esophageal squamous cell carcinoma radiosensitivity by inhibiting ferroptosis

10.6084/m9.figshare.16456890.v1figshare

Additional file 2 of SLC7A11 regulated by NRF2 modulates esophageal squamous cell carcinoma radiosensitivity by inhibiting ferroptosis