Translation initiation mediated by RNA looping is a research paper published in Proceedings of the National Academy of Sciences (2015). On theSindex it has a DataRank of 2.4. It has been cited 65 times, with 61 citing works in its 1-hop citation network.
Significance “Ribosomal scanning” is the generally accepted hypothesis for explaining how eukaryotic 40S ribosomal subunits find initiation codons. Some recently described phenomena cannot be explained by the ribosomal scanning hypothesis, however. Here we show that 43S ribosomal complexes recruited to locations downstream of a reporter gene can direct translation of the reporter independent of the 5′ end, suggesting that 43S ribosomal complex recognizes the initiation codon by “RNA looping” of the intervening mRNA segment between the ribosome recruiting site and the initiation codon. Moreover, we provide a mathematical model for the RNA looping hypothesis. The RNA looping hypothesis provides a logical explanation for translational augmentation by translation-enhancing elements located upstream and/or downstream of a protein-coding region.
FAIR checklist signals are shown for context only and do not affect DataRank scoring.
Base Score Contribution
0.628
From this paper's citation signal
Citation Network Contribution
1.8
From 52 citing papers with measurable signal
Ranked by citation count — the same ordering the engine uses when summing log1p(Cq) over citers.
DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 26% comes from its base citations and 74% from the citation network (52 citing papers contributed measurable signal).
Citers are pulled from OpenAlex sorted by cited_by_count:descand capped per paper, so when the cap binds we keep the highest-signal references and the score is reproducible across reruns.
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