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Homoharringtonine deregulates MYC transcriptional expression by directly binding NF-κB repressing factor

Proceedings of the National Academy of Sciences(2019)10.1073/pnas.1818539116Source: DataRank Database

Homoharringtonine deregulates MYC transcriptional expression by directly binding NF-κB repressing factor is a research paper published in Proceedings of the National Academy of Sciences (2019). On theSindex it has a DataRank of 3.1. It has been cited 113 times, with 84 citing works in its 1-hop citation network.

N/A

3.1DataRank · unranked

Scored on demand from live citation data

113 citations · 84 citing works in its network

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doi

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (5 grants)Impact (FWCI 7.41)OA: closedTopics (64)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (0/2)

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 23%Citation Network 77%

Base Score Contribution

0.710

From this paper's citation signal

Citation Network Contribution

2.4

From 70 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 84 citers.

Homoharringtonine inhibits the NOTCH/MYC pathway and exhibits antitumor effects in T-cell acute lymphoblastic leukemia
Blood202417 citations24 referencesContributes 0.120
An anticancer agent-loaded PLGA nanomedicine with glutathione-response and targeted delivery for the treatment of lung cancer
Journal of Materials Chemistry B201948 citations37 referencesContributes 0.105
Harringtonine Ester Derivatives with Enhanced Antiproliferative Activities against HL-60 and HeLa Cells
Journal of Natural Products202212 citations26 referencesContributes 0.099
Venetoclax Combined with Azacitidine and Homoharringtonine in Relapsed/Refractory AML: A Multicenter, Phase 2 Trial
Journal of Hematology & Oncology202372 citations51 referencesContributes 0.084
Homoharringtonine Attenuates Dextran Sulfate Sodium-Induced Colitis by Inhibiting NF-κB Signaling
Mediators of Inflammation202213 citations33 referencesContributes 0.080

Authors (19)

Wei-Na Zhang,Bing Chen ORCID,Wen-Da Xi,Ying Lu ORCID,Jinyan Huang ORCID

Live enrichment

PubMed:30659143 PMC:PMC6369765 OpenAlex:https://openalex.org/W2911121386

National Natural Science Foundation of China

Grant: 81470311

National Natural Science Foundation of China

Grant: 81670137

National Natural Science Foundation of China

Grant: 81270619

Samuel Waxman Cancer Research Foundation

Grant: No reference number

Academy of Medical Sciences

Grant: NAF\R1\180216

FWCI

7.41

Citation Percentile

1.0%

Citation Trend

2018

2019

2020

2021

2022

2023

2024

2025

2026

closedLicense: https://www.pnas.org/site/aboutpnas/licenses.xhtml

publisherhttp://www.pnas.org/syndication/doi/10.1073/pnas.1818539116

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.1818539116

journalhttps://doi.org/10.1073/pnas.1818539116

repositoryhttps://pubmed.ncbi.nlm.nih.gov/30659143

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/6369765

Fields of Study

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processesRNA Research and SplicingAnimalsBinding SitesBiomarkers, TumorCell Line, TumorChromosomes, Human, Pair 21Chromosomes, Human, Pair 8Disease Models, AnimalDose-Response Relationship, DrugGene Expression RegulationGenes, mycHomoharringtonineHumansLeukemia, Myeloid, AcuteMiceProtein BindingProtein Interaction Domains and MotifsProto-Oncogene Proteins c-kitRepressor ProteinsTranscription Factor RelATranscription, GeneticTranslocation, GeneticXenograft Model Antitumor Assays

MeSH Terms

HomoharringtonineAnimalsBinding SitesChromosomes, Human, Pair 21Chromosomes, Human, Pair 8Disease Models, AnimalDose-Response Relationship, DrugGene Expression RegulationHumansProtein BindingRepressor ProteinsTranscription, GeneticTranslocation, GeneticBiomarkers, TumorLeukemia, Myeloid, AcuteGenes, mycProto-Oncogene Proteins c-kitXenograft Model Antitumor AssaysCell Line, TumorMiceTranscription Factor RelAProtein Interaction Domains and Motifs

Keywords

HomoharringtonineTransactivationCore binding factorCancer researchMyeloid leukemiaLeukemiaGeneChemistryTranscription factorBiologyMolecular biologyGeneticsBiochemistryKitMYCAcute myelogenous leukemiaNf-κb Repressing Factor

Sustainable Development Goals

SDG 0: Good health and well-being

Related Papers (1)

Single-Cell Transcriptomic Analysis Defines Heterogeneity and Transcriptional Dynamics in the Adult Neural Stem Cell Lineage

N/A

8.8DataRank · unranked

Cell Reports(2017)

co-cited

10.1016/j.celrep.2016.12.060

Homoharringtonine deregulates MYC transcriptional expression by directly binding NF-κB repressing factor

FAIR Checklist

DataRank Breakdown

Top 5 citers driving the network score

Authors (19)

Funding (5 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)

Related Papers (1)