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FEN1 endonuclease as a therapeutic target for human cancers with defects in homologous recombination

Proceedings of the National Academy of Sciences(2020)10.1073/pnas.2009237117Source: DataRank Database

FEN1 endonuclease as a therapeutic target for human cancers with defects in homologous recombination is a research paper published in Proceedings of the National Academy of Sciences (2020). On theSindex it has a DataRank of 0. It has been cited 99 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access99 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (6 grants)Impact (FWCI 3.88)OA: bronzeTopics (61)IDs (PubMed, PMC, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (8)

Yuki Ishii ORCID,J. Mueller ORCID,Anjana Srivatsan ORCID,Timothy C. Gahman,Christopher D. Putnam ORCID

Live enrichment

PubMed:32719125 PMC:PMC7431096 OpenAlex:https://openalex.org/W3046182546

HHS | NIH | National Institute of General Medical Sciences

Grant: GM26017

Ludwig Institute for Cancer Research

Grant: No Number

NCI NIH HHS

Grant: T32 CA067754

NCI NIH HHS

Grant: P30 CA023100

NIGMS NIH HHS

Grant: R37 GM026017

NIGMS NIH HHS

Grant: R01 GM026017

FWCI

3.88

Citation Percentile

1.0%

Citation Trend

2020

2021

2022

2023

2024

2025

2026

bronzeLicense: https://creativecommons.org/licenses/by-nc-nd/4.0/

journalhttps://www.pnas.org/content/pnas/117/32/19415.full.pdf

publisherhttps://www.pnas.org/content/pnas/117/32/19415.full.pdf

publisherhttp://www.pnas.org/syndication/doi/10.1073/pnas.2009237117

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2009237117

journalhttps://doi.org/10.1073/pnas.2009237117

Fields of Study

DNA Repair MechanismsCRISPR and Genetic EngineeringPARP inhibition in cancer therapyAnimalsAntineoplastic AgentsBRCA1 ProteinBRCA2 ProteinCell Line, TumorDNA DamageDNA RepairDNA ReplicationFlap EndonucleasesGenomic InstabilityHomologous RecombinationHumansMiceNeoplasmsRNA, Small InterferingSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSmall Molecule LibrariesSynthetic Lethal MutationsXenograft Model Antitumor Assays

MeSH Terms

Synthetic Lethal MutationsAnimalsAntineoplastic AgentsDNA DamageDNA RepairDNA ReplicationHumansNeoplasmsSaccharomyces cerevisiaeBRCA1 ProteinXenograft Model Antitumor AssaysBRCA2 ProteinSaccharomyces cerevisiae ProteinsRNA, Small InterferingGenomic InstabilityFlap EndonucleasesCell Line, TumorMiceSmall Molecule LibrariesHomologous Recombination

Keywords

Synthetic lethalityHomologous recombinationGene knockdownDNA repairBiologyCancer researchEndonucleaseCancerMutantCell cultureHomologous chromosomeSaccharomyces cerevisiaeMolecular biologyGeneticsDNAGeneDNA replicationCancer therapy

Sustainable Development Goals

SDG 0: Good health and well-being