🏆 Finalist — NIH Data Sharing Index (“S-Index”) Challenge

Pilot corpus: NIH-funded biomedical datasets. Any DOI can be scored on demand — network effects sharpen as coverage grows.

Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion

Proceedings of the National Academy of Sciences(2020)10.1073/pnas.2012197117Source: DataRank Database

Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion is a research paper published in Proceedings of the National Academy of Sciences (2020). On theSindex it has a DataRank of 0. It has been cited 256 times.

N/A

0DataRank · unranked

Scored on demand from live citation data

Open Access256 citations

Cite:

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (20 grants)OA: hybridTopics (46)IDs (PubMed)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

FAIR checklist signals are shown for context only and do not affect DataRank scoring.

Run a calibrated FAIR evaluation for this paper →

We only score data papers we can read in full — never from an abstract alone.

Authors (27)

James Brett Case ORCID,Eylan Yutuc ORCID,Xiucui Ma,Sheng Shen ORCID,María Florencia Gómez Castro ORCID

Live enrichment

PubMed:33239446

RCUK | Biotechnology and Biological Sciences Research Council

Grant: BB/L001942/1

Identification of endogenous ligands for the Retinoid-related Orphan Receptor gamma

HHS | NIH | National Institute of Allergy and Infectious Diseases

Grant: R00 AI135031

HHS | NIH | National Institute of Allergy and Infectious Diseases

Grant: R01 AI150796

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Grant: P30 DK052574

HHS | NIH | National Institute of Allergy and Infectious Diseases

Grant: R01 AI127828

HHS | NIH | National Institute of Allergy and Infectious Diseases

Grant: 75N93019C00062

DOD | Defense Advanced Research Projects Agency

Grant: HR001117S0019

HHS | NIH | National Institute of Allergy and Infectious Diseases

Grant: R37 AI059371

Helen Hay Whitney Foundation

Grant: postdoctoral fellowship

National Institutes of Health

Grant: 1P30DK052574-01A1

Core--Transgenic mouse and stem cell

National Institutes of Health

Grant: 4R00AI135031-02

Genetic and Biochemical Interrogation of Rotavirus-Cohesin Interaction

National Institutes of Health

Grant: 5R37AI059371-15

RNA Processing in Non-Segmented Minus-Strand RNA Viruses

National Institutes of Health

Grant: 5T32AI007245-25

Molecular Basis of Viral Infectivity

National Institutes of Health

Grant: 5R01AI150796-05

Interferon-Stimulated Gene Inhibition of Rotavirus Replication and Viral Antagonism

National Institutes of Health

Grant: 5R01AI127828-05

Human neutralizing antibodies for Zika virus

NIGMS NIH HHS

Grant: R35 GM130386

NHLBI NIH HHS

Grant: R01 HL107594

NIAID NIH HHS

Grant: T32 AI007245

NIH HHS

Grant: GM130386

BLRD VA

Grant: I01 BX004235

hybridLicense: cc-by

publisherhttps://doi.org/10.1073/pnas.2012197117

publisherhttp://www.pnas.org/syndication/doi/10.1073/pnas.2012197117

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2012197117

repositoryhttps://digitalcommons.wustl.edu/cgi/viewcontent.cgi?article=11009&context=open_access_pubs

repositoryhttp://hdl.handle.net/1805/25653

Fields of Study

0301 basic medicine03 medical and health sciencesAntiviral AgentsCOVID-19EndosomesHumansHydroxycholesterolsInterferonsMembrane FusionSevere acute respiratory syndrome-related coronavirusSARS-CoV-2Spike Glycoprotein, CoronavirusVirus InternalizationVirus ReplicationCOVID-19 Drug Treatment

MeSH Terms

Antiviral AgentsCOVID-19EndosomesHumansHydroxycholesterolsInterferonsMembrane FusionSevere acute respiratory syndrome-related coronavirusSARS-CoV-2Spike Glycoprotein, CoronavirusVirus InternalizationVirus ReplicationCOVID-19 Drug Treatment

Keywords

MultidisciplinarySARS-CoV-2COVID-19interferonEndosomesvirus entryBiological SciencesVirus InternalizationVirus ReplicationAntiviral AgentsMembrane FusionHydroxycholesterolsCOVID-19 Drug TreatmentSevere acute respiratory syndrome-related coronavirusSpike Glycoprotein, CoronavirusHumansInterferonsinnate immunity

Sustainable Development Goals

SDG 3: 3. Good health