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CAG RNAs induce DNA damage and apoptosis by silencing NUDT16 expression in polyglutamine degeneration

Proceedings of the National Academy of Sciences(2021)10.1073/pnas.2022940118Source: DataRank Database

CAG RNAs induce DNA damage and apoptosis by silencing NUDT16 expression in polyglutamine degeneration is a research paper published in Proceedings of the National Academy of Sciences (2021). On theSindex it has a DataRank of 0. It has been cited 35 times.

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Open Access35 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (8 grants)Impact (FWCI 2.87)OA: hybridTopics (86)Linked Datasets (8)DataCite Reuse (8)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

DataCite relations
Linked datasets

Reusable (0/3)

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Authors (23)

Pei Guo ORCID,Xiao Lin ORCID,Ying An ORCID,Kong Hung Sze,Matthew Ho Yan Lau

Live enrichment

PubMed:33947817 PMC:PMC8126783 OpenAlex:https://openalex.org/W3159972466

Research Grants Council, University Grants Committee

Grant: 14107118

Research Grants Council, University Grants Committee

Grant: 14122019

Chinese University of Hong Kong

Grant: 4930713

Chinese University of Hong Kong

Grant: VCF2014011

Chinese University of Hong Kong

Grant: 8303404

Chinese University of Hong Kong

Grant: 7105306

Office of Extramural Research, National Institutes of Health

Grant: R01AR069645

National Institutes of Health

Grant: 5R01AR069645-05

Small Molecule Approaches to Targeting the DNA and RNA in Myotonic Dystrophy

FWCI

2.87

Citation Percentile

0.9%

Citation Trend

2021

2022

2023

2024

2025

2026

hybridLicense: cc-by-nc-nd

journalhttps://www.pnas.org/content/pnas/118/19/e2022940118.full.pdf

HYBRIDhttps://www.pnas.org/content/pnas/118/19/e2022940118.full.pdf

publisherhttps://www.pnas.org/content/pnas/118/19/e2022940118.full.pdf

publisherhttp://www.pnas.org/syndication/doi/10.1073/pnas.2022940118

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2022940118

Fields of Study

Genetic Neurodegenerative DiseasesRNA Research and SplicingMitochondrial Function and PathologyMedicineBiology0301 basic medicine03 medical and health sciences0303 health sciencesAnimalsApoptosisBenzamidinesCell Line, TumorDNA DamageDisease Models, AnimalGene Expression RegulationHumansHuntingtin ProteinHuntington DiseaseMice, Inbred C57BLMice, TransgenicMolecular Dynamics SimulationPeptidesPyrophosphatasesRNARNA InterferenceRNA, MessengerTrinucleotide Repeat ExpansionMice

MeSH Terms

Huntingtin ProteinAnimalsBenzamidinesDisease Models, AnimalDNA DamageGene Expression RegulationHumansHuntington DiseaseMice, Inbred C57BLMice, TransgenicPeptidesPyrophosphatasesRNARNA, MessengerApoptosisTrinucleotide Repeat ExpansionRNA InterferenceCell Line, TumorMiceMolecular Dynamics Simulation

Keywords

Gene silencingDNA damageBiologyCell biologyRNADNARNA silencingRNA interferenceMessenger RNASmall interfering RNAGeneDNA repairMolecular biologyHeteroduplexGene expressionApoptosisGeneticsHuntington’s DiseaseR6/2Nudt16Mice, TransgenicMolecular Dynamics SimulationMiceCell Line, TumorAnimalsHumansRNA, MessengerPyrophosphatasesHuntingtin ProteinDNA damage; Huntington’s disease; NUDT16; R6/2Biological SciencesBenzamidinesMice, Inbred C57BLDisease Models, AnimalHuntington DiseaseGene Expression RegulationPeptidesTrinucleotide Repeat Expansion

Sustainable Development Goals

SDG 3: 3. Good health

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CAG RNAs induce DNA damage and apoptosis by silencing NUDT16 expression in polyglutamine degeneration

FAIR Checklist

Authors (23)

Funding (8 grants)

Impact

Open Access

Topics

Linked Datasets (8)

Annotations (Europe PMC)