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Inhibition of elastase enhances the adjuvanticity of alum and promotes anti–SARS-CoV-2 systemic and mucosal immunity

Proceedings of the National Academy of Sciences(2021)10.1073/pnas.2102435118Source: DataRank Database

Inhibition of elastase enhances the adjuvanticity of alum and promotes anti–SARS-CoV-2 systemic and mucosal immunity is a research paper published in Proceedings of the National Academy of Sciences (2021). On theSindex it has a DataRank of 0.505. It has been cited 28 times.

N/A

0.505DataRank · unranked

Scored on demand from live citation data

Open Access28 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (16 grants)Impact (FWCI 1.36)OA: hybridTopics (66)IDs (PubMed, PMC, OpenAlex)Annotations (3)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.505

From this paper's citation signal

Citation Network Contribution

Citation network not refreshed for this result

This paper's DataRank is currently driven only by its base citation score. Citation network data was not refreshed for this result.

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Authors (16)

Zayed Attia ORCID,Rachel M. Woodfint,Cong Zeng ORCID,Sun Hee Kim ORCID,Haley Steiner

Live enrichment

PubMed:34353890 PMC:PMC8403952 OpenAlex:https://openalex.org/W3191329109

HHS | National Institutes of Health

Grant: R01AI18958

HHS | National Institutes of Health

Grant: R01DK101323

HHS | National Institutes of Health

Grant: and R01AI145144

HHS|National Institutes of Heath

Grant: U54CA260582

HHS | National Institutes of Health

Grant: NIH R01AI150473

NIAID NIH HHS

Grant: R01 AI123661

NIAID NIH HHS

Grant: R01 AI150473

NIH HHS

Grant: T35 OD010977

NIAID NIH HHS

Grant: R01 AI018958

NIAID NIH HHS

Grant: R01 AI124121

NIAID NIH HHS

Grant: R01 AI145144

National Institutes of Health

Grant: 3R01AI018958-14A1S1

CELLULAR AND MOLECULAR MECHANISMS FOR MUCOSAL IMMUNITY

National Institutes of Health

Grant: 5R01AI145144-02

Targeting myeloid cells for regulation of alum-based immunity

National Institutes of Health

Grant: 5R01DK101323-05

Regulation of mucosal IgA and allergic inflammation by intestinal epithelial cells

National Institutes of Health

Grant: 3U54CA260582-02S3

Center for serological testing to improve outcomes from pandemic COVID-19 (STOP-COVID)

National Institutes of Health

Grant: 5R01AI150473-04

TIM-mediated Inhibition of HIV Release: Cooperation with SERINC and Antagonism by Nef

FWCI

1.36

Citation Percentile

0.8%

Citation Trend

2021

2022

2023

2024

2025

2026

hybridLicense: cc-by

journalhttps://doi.org/10.1073/pnas.2102435118

publisherhttps://doi.org/10.1073/pnas.2102435118

publisherhttp://www.pnas.org/syndication/doi/10.1073/pnas.2102435118

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2102435118

repositoryhttps://pubmed.ncbi.nlm.nih.gov/34353890

Fields of Study

SARS-CoV-2 and COVID-19 ResearchImmunotherapy and Immune ResponsesInflammasome and immune disorders0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

COVID-19SARS-CoV-2COVID-19 Drug TreatmentAdjuvants, ImmunologicAlum CompoundsAnimalsAntibodies, ViralAntibody FormationEnzyme InhibitorsHumansImmunoglobulin AImmunity, InnateMice, Inbred C57BLSwineMice, KnockoutTh1 CellsImmunity, MucosalLeukocyte ElastaseMiceAntibodies, NeutralizingHEK293 CellsSpike Glycoprotein, Coronavirus

Keywords

AdjuvantAlumInnate immune systemAntibodyImmunologyImmunityElastaseImmune systemVaccinationHumoral immunityBiologyMicrobiologyChemistryEnzymeBiochemistryMucosal immunityNeutrophil Elastase InhibitorSars-cov-2Mice, KnockoutSwineCOVID-19Biological SciencesAntibodies, ViralAntibodies, NeutralizingImmunity, InnateImmunoglobulin AMice, Inbred C57BLMiceHEK293 CellsAdjuvants, ImmunologicAntibody FormationSpike Glycoprotein, CoronavirusAlum CompoundsAnimalsHumansEnzyme InhibitorsLeukocyte ElastaseImmunity, Mucosal

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being