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aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete, β-arrestin-2–mediated SphK1-S1PR1-Akt signaling axis

Proceedings of the National Academy of Sciences(2021)10.1073/pnas.2106623118Source: DataRank Database

aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete, β-arrestin-2–mediated SphK1-S1PR1-Akt signaling axis is a research paper published in Proceedings of the National Academy of Sciences (2021). On theSindex it has a DataRank of 0. It has been cited 30 times.

N/A

0DataRank · unranked

Scored on demand from live citation data

Open Access30 citations

Cite:

Linked data & code

uniprot

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (16 grants)Impact (FWCI 1.48)OA: greenTopics (95)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (14)

Cierra A. Birch,Dequina Nicholas ORCID,Lennis B. Orduña-Castillo ORCID,Metztli Cisneros‐Aguirre ORCID,Anand Patwardhan ORCID

Live enrichment

PubMed:34873055 PMC:PMC8670512 OpenAlex:https://openalex.org/W4226047610

Foundation for the National Institutes of Health

Grant: R35GM127121

Foundation for the National Institutes of Health

Grant: K12GM068524

Foundation for the National Institutes of Health

Grant: R25GM083275

Foundation for the National Institutes of Health

Grant: P50HD12303

Foundation for the National Institutes of Health

Grant: HL007444

NICHD NIH HHS

Grant: R00 HD098330

NICHD NIH HHS

Grant: P50 HD012303

NIGMS NIH HHS

Grant: R01 GM116597

BLRD VA

Grant: I01 BX001963

NHLBI NIH HHS

Grant: T32 HL007444

National Institutes of Health

Grant: 5K12GM068524-09

San Diego IRACDA: Professors for the Future

National Institutes of Health

Grant: 5R35GM127121-05

Cell Signaling by Protease-activated G Protein-coupled Receptors

National Institutes of Health

Grant: 3P50HD012303-13S1

CONTROL OF THE HYPOTHALAMIC-HYPOPHYSEAL-OVARIAN SYSTEM

National Institutes of Health

Grant: 5R25GM083275-07

Mentoring Young Minds to Increase Diversity in the Biomedical Research

National Institutes of Health

Grant: 5T32HL007444-39

Training in Cardiovascular Physiology and Pharmacology

National Institutes of Health

Grant: 5R01GM116597-02

GPCR Cytoprotective Signaling Mechanisms

FWCI

1.48

Citation Percentile

0.8%

Influential Citations

1

Citation Trend

2022

2023

2024

2025

2026

greenLicense: https://www.pnas.org/site/aboutpnas/licenses.xhtml

repositoryhttps://escholarship.org/content/qt1w04n9qg/qt1w04n9qg.pdf?t=rwwni2

BRONZEhttps://www.pnas.org/doi/pdf/10.1073/pnas.2106623118

repositoryhttps://escholarship.org/content/qt1w04n9qg/qt1w04n9qg.pdf?t=rwwni2

publisherhttp://www.pnas.org/syndication/doi/10.1073/pnas.2106623118

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2106623118

Fields of Study

Receptor Mechanisms and SignalingSphingolipid Metabolism and SignalingATP Synthase and ATPases ResearchMedicineBiology0301 basic medicine03 medical and health sciencesAnilidesApoptosisEndothelial CellsEnzyme InhibitorsGene Expression RegulationHeterocyclic Compounds, 3-RingHumansLactonesMethanolOrganophosphonatesPhosphotransferases (Alcohol Group Acceptor)Platelet Aggregation InhibitorsProtein CProto-Oncogene Proteins c-aktPyridinesPyrrolidinesReceptor, PAR-1Sphingosine-1-Phosphate ReceptorsSulfonesbeta-Arrestin 2Sphingosine Kinase

MeSH Terms

beta-Arrestin 2Sphingosine-1-Phosphate ReceptorsSphingosine KinaseMethanolAnilidesEnzyme InhibitorsGene Expression RegulationHeterocyclic Compounds, 3-RingHumansLactonesPlatelet Aggregation InhibitorsProtein CPyridinesPyrrolidinesSulfonesApoptosisPhosphotransferases (Alcohol Group Acceptor)Endothelial CellsReceptor, PAR-1Proto-Oncogene Proteins c-aktOrganophosphonates

Keywords

S1PR1Protein kinase BApoptosisChemistryCell biologySignal transductionCancer researchBiologyBiochemistryVEGF receptorsVascular endothelial growth factor ACytoprotectionendothelial dysfunctionGpcrBiased Signaling570PyrrolidinesPyridines1.1 Normal biological development and functioningOrganophosphonates610PAR-13-RingLactonesHeterocyclic Compounds2.1 Biological and endogenous factorsHumansAnilidesReceptor, PAR-1SulfonesEnzyme InhibitorsSphingosine-1-Phosphate ReceptorsBiomedical and Clinical SciencesMethanolEndothelial CellsBiological Sciencesbeta-Arrestin 2Phosphotransferases (Alcohol Group Acceptor)Infectious DiseasesGene Expression RegulationBiochemistry and Cell BiologyHeterocyclic Compounds, 3-RingProto-Oncogene Proteins c-aktPlatelet Aggregation InhibitorsReceptorProtein C

Sustainable Development Goals

SDG 0: Good health and well-being