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Early expression of mature αβ TCR in CD4 − CD8 − T cell progenitors enables MHC to drive development of T-ALL bearing NOTCH mutations

Proceedings of the National Academy of Sciences(2022)10.1073/pnas.2118529119Source: DataRank Database

Early expression of mature αβ TCR in CD4 − CD8 − T cell progenitors enables MHC to drive development of T-ALL bearing NOTCH mutations is a research paper published in Proceedings of the National Academy of Sciences (2022). On theSindex it has a DataRank of 0. It has been cited 4 times.

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Open Access4 citations

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Enrichment:Funding (5 grants)Impact (FWCI 0.37)OA: greenTopics (53)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (16)

Robert J. Stiles ORCID,Melissa Ludescher,Tessa R. Davis ORCID,Shariq S. Khwaja,Richard J. Bram ORCID

Live enrichment

PubMed:35767640 PMC:PMC9271211 OpenAlex:https://openalex.org/W4283695935

American Association of Immunologists

Grant: Intersect Fellowship

HHS | National Institutes of Health

Grant: R01GM103841

NIAID NIH HHS

Grant: R01 AI097187

NCI NIH HHS

Grant: U01 CA244314

National Institutes of Health

Grant: 1R01GM103841-01A1

Measuring multiprotein assemblies that drive biological signals

FWCI

0.37

Citation Percentile

0.6%

Citation Trend

2024

2025

greenLicense: cc-by-nc-nd

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/9271211

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2118529119

journalhttps://doi.org/10.1073/pnas.2118529119

repositoryhttps://pubmed.ncbi.nlm.nih.gov/35767640

Fields of Study

CAR-T cell therapy researchAcute Lymphoblastic Leukemia researchImmune Cell Function and Interaction0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

AnimalsCell DifferentiationHistocompatibility AntigensHumansMajor Histocompatibility ComplexMice, Inbred C57BLMice, TransgenicMutationReceptors, Antigen, T-CellThymus GlandReceptors, Antigen, T-Cell, alpha-betaCD8-Positive T-LymphocytesMiceReceptor, Notch1Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Keywords

BiologyT-cell receptorMajor histocompatibility complexCD8T cellPopulationCell biologyCD3Molecular biologyAntigenImmunologyImmune systemLeukemiaTCRMHCNotchT-allReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-CellCell DifferentiationMice, TransgenicThymus GlandBiological SciencesCD8-Positive T-LymphocytesPrecursor T-Cell Lymphoblastic Leukemia-LymphomaMice, Inbred C57BLMiceHistocompatibility AntigensMutationAnimalsHumansReceptor, Notch1

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Early expression of mature αβ TCR in CD4 − CD8 − T cell progenitors enables MHC to drive development of T-ALL bearing NOTCH mutations

FAIR Checklist

Authors (16)

Funding (5 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)