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A vasculature niche orchestrates stromal cell phenotype through PDGF signaling: Importance in human fibrotic disease

Proceedings of the National Academy of Sciences(2022)10.1073/pnas.2120336119Source: DataRank Database

A vasculature niche orchestrates stromal cell phenotype through PDGF signaling: Importance in human fibrotic disease is a research paper published in Proceedings of the National Academy of Sciences (2022). On theSindex it has a DataRank of 0.918. It has been cited 27 times, with 23 citing works in its 1-hop citation network.

N/A

0.918DataRank · unranked

Scored on demand from live citation data

27 citations · 23 citing works in its network

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Linked data & code

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DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (8 grants)Impact (FWCI 3.69)OA: hybridTopics (39)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (0/2)

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 54%Citation Network 46%

Base Score Contribution

0.500

From this paper's citation signal

Citation Network Contribution

0.418

From 17 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 23 citers.

Cancer-Associated Fibroblasts Promote Lymphatic Metastasis in Cholangiocarcinoma via the PDGF-BB/PDGFR-β Mediated Paracrine Signaling Network
Aging and Disease202336 citations42 referencesContributes 0.086
PDGF-D Prodomain Differentially Inhibits the Biological Activities of PDGF-D and PDGF-B
Journal of Molecular Biology202210 citations32 referencesContributes 0.075
Extracellular matrix remodelling in dental pulp tissue of carious human teeth through the prism of single-cell RNA sequencing
International Journal of Oral Science202326 citations68 referencesContributes 0.048
C-X-C domain ligand 14-mediated stromal cell–macrophage interaction as a therapeutic target for hand dermal fibrosis
Communications Biology202311 citations65 referencesContributes 0.038
Diabetes Induces Cardiac Fibroblast Activation, Promoting a Matrix‐Preserving Nonmyofibroblast Phenotype, Without Stimulating Pericyte to Fibroblast Conversion
Journal of the American Heart Association202321 citations83 referencesContributes 0.037

Authors (9)

Lynn Williams,Nan Yang ORCID,Mingjun Zhang,Carl Lee,Marc Feldmann ORCID

Live enrichment

PubMed:35320046 PMC:PMC9060460 OpenAlex:https://openalex.org/W4220905187

Royal College of Surgeons of England

Grant: AZR0010

British Society for Surgery of the Hand

Grant: AZR01250

Kennedy Trust

Grant: KENN202117

Kennedy Trust

Grant: KENN161710

Kennedy Institute

Grant: AZT00040-AZ06 (Carl)

Kennedy Trust

Grant: KENN202103

Wellcome Trust

Grant: unidentified

unidentified

Wellcome Trust

FWCI

3.69

Citation Percentile

0.9%

Citation Trend

2022

2023

2024

2025

2026

hybridLicense: cc-by

journalhttps://doi.org/10.1073/pnas.2120336119

publisherhttps://doi.org/10.1073/pnas.2120336119

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2120336119

repositoryhttps://pubmed.ncbi.nlm.nih.gov/35320046

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/9060460

Fields of Study

Dupuytren's Contracture and TreatmentsGenetic factors in colorectal cancerTumors and Oncological Cases0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

Dupuytren ContractureFibrosisHumansPhenotypeStromal CellsMyofibroblastsTumor Microenvironment

Keywords

MyofibroblastStromal cellPericytePathologyBiologyPhenotypeFibrosisMesenchymal stem cellPopulationLungCell biologyCancer researchMedicineEndothelial stem cellGeneticsGeneInflammationPDGFVasculatureSingle-cell SequencingDupuytren ContractureTumor MicroenvironmentHumansBiological SciencesStromal CellsMyofibroblasts

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Related Papers (2)

Transcriptomic characterization of lung pericytes in systemic sclerosis-associated pulmonary fibrosis

N/A

0.455DataRank · unranked

iScience(2024)

co-cited

10.1016/j.isci.2024.110010

A novel lineage restricted, pericyte-like cell line isolated from human embryonic stem cells

N/A

1.2DataRank · unranked

Scientific Reports(2016)

co-cited

10.1038/srep24403

A vasculature niche orchestrates stromal cell phenotype through PDGF signaling: Importance in human fibrotic disease

FAIR Checklist

DataRank Breakdown

Top 5 citers driving the network score

Authors (9)

Funding (8 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)

Related Papers (2)