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Tropism of SARS-CoV-2 for human cortical astrocytes

Proceedings of the National Academy of Sciences(2022)10.1073/pnas.2122236119Source: DataRank Database

Tropism of SARS-CoV-2 for human cortical astrocytes is a research paper published in Proceedings of the National Academy of Sciences (2022). On theSindex it has a DataRank of 3.6. It has been cited 163 times, with 153 citing works in its 1-hop citation network.

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3.6DataRank · unranked

Scored on demand from live citation data

Open Access163 citations · 153 citing works in its network

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Linked data & code

doi

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (14 grants)Impact (FWCI 17.53)OA: hybridTopics (72)Linked Datasets (2)DataCite Reuse (2)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

DataCite relations
Linked datasets

Reusable (0/3)

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DataRank Breakdown

Base Score 22%Citation Network 78%

Base Score Contribution

0.765

From this paper's citation signal

Citation Network Contribution

2.8

From 131 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 153 citers.

In SARS-CoV-2, astrocytes are in it for the long haul
Proceedings of the National Academy of Sciences202229 citations18 referencesContributes 0.189
The original strain of SARS-CoV-2, the Delta variant, and the Omicron variant infect microglia efficiently, in contrast to their inability to infect neurons: Analysis using 2D and 3D cultures
Experimental Neurology202324 citations27 referencesContributes 0.119
Physical activity and long COVID: findings from the Prospective Study About Mental and Physical Health in Adults cohort
Public Health202333 citations31 referencesContributes 0.114
Protocol to detect infectious SARS-CoV-2 at low levels using in situ hybridization techniques
STAR Protocols20234 citations15 referencesContributes 0.107
SARS-CoV-2 infects neurons, astrocytes, choroid plexus epithelial cells and pericytes of the human central nervous system in vitro
Journal of General Virology202423 citations41 referencesContributes 0.078

Authors (28)

Tanzila Mukhtar ORCID,Ugomma C. Eze ORCID,Camille R. Simoneau ORCID,Jayden Ross ORCID,Neelroop Parikshak ORCID

Live enrichment

PubMed:35858406 PMC:PMC9335272 OpenAlex:https://openalex.org/W4285089313

HHS | NIH | National Institute of Mental Health

Grant: U01MH114825

HHS | NIH | National Institute of Neurological Disorders and Stroke

Grant: R35NS097305

HHS | NIH | National Institute on Drug Abuse

Grant: 5DP1DA038043

HHS | NIH | National Institute of Mental Health

Grant: 5K99MH125329-02

Improving Brain Organoid Models by Mediating Metabolic Dysregulation

NIMH NIH HHS

Grant: R00 MH125329

NINDS NIH HHS

Grant: R01 NS123263

NIDA NIH HHS

Grant: DP1 DA038043

NIMH NIH HHS

Grant: K99 MH125329

NINDS NIH HHS

Grant: R25 NS070680

National Institutes of Health

Grant: 1K99MH125329-01

Improving Brain Organoid Models by Mediating Metabolic Dysregulation

National Institutes of Health

Grant: 5R25NS070680-04

Educating Physician-Neuroscientists: The R25 at UCSF

National Institutes of Health

Grant: 3R35NS097305-06S1

Development and Expansion of the Human Cerebral Cortex

National Institutes of Health

Grant: 5DP1DA038043-03

A new model of accelerated immune aging in HIV-infected drug users

National Institutes of Health

Grant: 5U01MH114825-03

A Cellular Resolution Census of the Developing Human Brain

FWCI

17.53

Citation Percentile

1.0%

Influential Citations

Citation Trend

2022

2023

2024

2025

2026

hybridLicense: cc-by

journalhttps://doi.org/10.1073/pnas.2122236119

HYBRIDhttps://doi.org/10.1073/pnas.2122236119

publisherhttps://doi.org/10.1073/pnas.2122236119

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2122236119

repositoryhttps://pubmed.ncbi.nlm.nih.gov/35858406

Fields of Study

Long-Term Effects of COVID-19SARS-CoV-2 and COVID-19 ResearchCOVID-19 and Mental HealthMedicineBiology0301 basic medicine03 medical and health sciencesAngiotensin-Converting Enzyme 2AstrocytesCerebral CortexHumansOrganoidsPrimary Cell CultureSARS-CoV-2Viral Tropism

MeSH Terms

Angiotensin-Converting Enzyme 2SARS-CoV-2AstrocytesCerebral CortexHumansOrganoidsViral TropismPrimary Cell Culture

Keywords

TropismBiologyOrganoidGliosisCoronavirusCell typeNeuroinflammationAstrocyteImmunologyTissue tropismMicrogliaInflammationCellCell biologyNeurosciencePathologyCoronavirus disease 2019 (COVID-19)MedicineVirusCentral nervous systemOrganoid ModelsAstrocyte ReactivitySars-cov-2 Tropism1.1 Normal biological development and functioningPrimary Cell Culture610Vaccine RelatedClinical ResearchUnderpinning researchBiodefense6162.1 Biological and endogenous factorsHumansAetiologyLungCerebral CortexSARS-CoV-2PreventionNeurosciencesPneumoniaBiological SciencesStem Cell ResearchOrganoidsViral TropismInfectious DiseasesEmerging Infectious DiseasesAstrocytesPneumonia & InfluenzaAngiotensin-Converting Enzyme 2

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Additional file 1 of Longitudinal positron emission tomography and postmortem analysis reveals widespread neuroinflammation in SARS-CoV-2 infected rhesus macaques

10.6084/m9.figshare.23804883.v1figshare

Additional file 1 of Longitudinal positron emission tomography and postmortem analysis reveals widespread neuroinflammation in SARS-CoV-2 infected rhesus macaques

10.6084/m9.figshare.23804883figshare