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Proximity interactome analysis of Lassa polymerase reveals eRF3a/GSPT1 as a druggable target for host-directed antivirals

Proceedings of the National Academy of Sciences(2022)10.1073/pnas.2201208119Source: DataRank Database

Proximity interactome analysis of Lassa polymerase reveals eRF3a/GSPT1 as a druggable target for host-directed antivirals is a research paper published in Proceedings of the National Academy of Sciences (2022). On theSindex it has a DataRank of 0. It has been cited 26 times.

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Open Access26 citations

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Enrichment:Funding (5 grants)OA: greenTopics (21)IDs (PubMed)SDGs (1)

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Authors (10)

Colette Pietzsch,Haydar Witwit ORCID,George Tsaprailis ORCID,Gogce Crynen ORCID,Kelvin F. Cho ORCID

Live enrichment

PubMed:35858434

HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases

Grant: AI125626

HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases

Grant: AI128556

National Institutes of Health

Grant: 1R01AI125626-01A1

A Virus-Free Cell Platform To Discover Inhibitors Of Lassa Fever Virus

National Institutes of Health

Grant: 1S10OD021831-01A1

Super-resolution confocal microscope

National Institutes of Health

Grant: 5R21AI128556-02

Modulation of Lassa Virus vRNP Activity By Host Cell Factors

greenLicense: cc-by-nc-nd

HYBRIDhttps://doi.org/10.1073/pnas.2201208119

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/9340056

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2201208119

https://doi.org/10.1101/2021.07.16.452739

https://www.biorxiv.org/content/biorxiv/early/2021/07/17/2021.07.16.452739.full.pdf

Fields of Study

BiologyMedicine0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

ProteomicsProteomeBiological SciencesIsoindolesRNA-Dependent RNA PolymeraseAntiviral AgentsViral ProteinsLassa FeverCell Line, TumorAcetamidesProteolysisHumansProtein Interaction MapsLassa virusPiperidonesPeptide Termination Factors

Sustainable Development Goals

SDG 3: 3. Good health