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Selective targeting of metastatic ovarian cancer using an engineered anthrax prodrug activated by membrane-anchored serine proteases

Proceedings of the National Academy of Sciences(2022)10.1073/pnas.2201423119Source: DataRank Database

Selective targeting of metastatic ovarian cancer using an engineered anthrax prodrug activated by membrane-anchored serine proteases is a research paper published in Proceedings of the National Academy of Sciences (2022). On theSindex it has a DataRank of 0. It has been cited 10 times.

N/A

0DataRank · unranked

Scored on demand from live citation data

Open Access10 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (16 grants)Impact (FWCI 0.79)OA: greenTopics (52)IDs (PubMed, PMC, OpenAlex)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (12)

Nisha R. Pawar ORCID,Erik W. Martin ORCID,Marguerite S. Buzza ORCID,Gregory D. Conway ORCID,Rena G. Lapidus ORCID

Live enrichment

PubMed:35867758 PMC:PMC9282395 OpenAlex:https://openalex.org/W4284897430

HHS | National Institutes of Health

Grant: R01 CA196988

HHS | National Institutes of Health

Grant: R01 HL118390

Mary Kay Foundation

Grant: N/A

HHS | National Institutes of Health

Grant: P30CA134274

HHS | National Institutes of Health

Grant: R01 CA254938

American Cancer Society

Grant: IRG-16-123-13

HHS | National Institutes of Health

Grant: T32CA154274

HHS | National Institutes of Health

Grant: T32GM008181

NIAID NIH HHS

Grant: R01 AI170574

NIGMS NIH HHS

Grant: R25 GM113262

National Institutes of Health

Grant: 5R01HL118390-02

Membrane Serine Protease Activities in Protease Activated Receptor Signaling

National Institutes of Health

Grant: 5T32CA154274-14

Training Grant in Cancer Biology

National Institutes of Health

Grant: 1R01CA254938-01

Developmental therapy for selectively targeting MEK-ERK pathway in cancer cells and tumor stromal compartment

National Institutes of Health

Grant: 2P30CA134274-04

Protocol Specific Research

National Institutes of Health

Grant: 3T32GM008181-28S1

Training Program in Integrative Membrane Biology

National Institutes of Health

Grant: 1R01CA196988-01A1

Protease activated receptor-2 (PAR-2) signaling and metastatic ovarian cancer

FWCI

0.79

Citation Percentile

0.7%

Citation Trend

2022

2023

2025

greenLicense: cc-by-nc-nd

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/9282395

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/9282395

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2201423119

journalhttps://doi.org/10.1073/pnas.2201423119

repositoryhttps://pubmed.ncbi.nlm.nih.gov/35867758

Fields of Study

Bacillus and Francisella bacterial researchMicrobial Inactivation MethodsToxin Mechanisms and Immunotoxins03 medical and health sciences0302 clinical medicine

MeSH Terms

Antigens, BacterialAntineoplastic AgentsBacterial ToxinsEnzyme PrecursorsFemaleHumansNeoplasm Recurrence, LocalOvarian NeoplasmsProdrugsSpheroids, CellularXenograft Model Antitumor AssaysCell Line, TumorSerine Proteases

Keywords

Ovarian cancerProteasesCancer researchOvarian tumorAnthrax toxinCytotoxic T cellCancerMedicineProdrugIn vivoBiologyPharmacologyInternal medicineIn vitroBiochemistryEnzymeFusion proteinascitesMetastatic Ovarian CancerMembrane-anchored Serine ProteasesOvarian NeoplasmsAntigens, BacterialEnzyme PrecursorsBacterial ToxinsAntineoplastic AgentsBiological SciencesXenograft Model Antitumor AssaysCell Line, TumorSpheroids, CellularHumansFemaleProdrugsNeoplasm Recurrence, LocalSerine Proteases

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being