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Trametinib ameliorates aging-associated gut pathology in Drosophila females by reducing Pol III activity in intestinal stem cells

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2311313121Source: DataRank Database

Trametinib ameliorates aging-associated gut pathology in Drosophila females by reducing Pol III activity in intestinal stem cells is a research paper published in Proceedings of the National Academy of Sciences (2024). On theSindex it has a DataRank of 0. It has been cited 15 times.

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Scored on demand from live citation data

Open Access15 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (12 grants)Impact (FWCI 2.57)OA: hybridTopics (50)IDs (PubMed, PMC, OpenAlex)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (11)

Bowen Xu ORCID,Jennifer C. Regan ORCID,Magda L. Atilano ORCID,Lucy J. Minkley ORCID,Danny Filer

Live enrichment

PubMed:38241436 PMC:PMC10823232 OpenAlex:https://openalex.org/W4391018039

UKRI | Biotechnology and Biological Sciences Research Council

Grant: BB/V006541/1

Mechanisms mediating the anti-ageing effects of trametinib.

Wellcome Trust

Grant: 098565/Z/12/Z

EC | European Research Council

Grant: 268739

Experimental Research into Ageing

EC | Horizon 2020 Framework Programme

Grant: 741989

Developing Geroprotectors to Prevent Polymorbidity

Biotechnology and Biological Sciences Research Council

Grant: BB/W013525/1

Wellcome Trust

Grant: 518230

NIH HHS

Grant: P40 OD018537

Biotechnology and Biological Sciences Research Council

Grant: BB/S014357/1

National Institutes of Health

Grant: 3P40OD018537-04S1

Bloomington Drosophila Stock Center at Indiana University

Wellcome Trust

Grant: 098565

Biological determinants of ageing and late life health, and their pharmacological manipulation.

Wellcome Trust

FWCI

2.57

Citation Percentile

0.9%

Citation Trend

2024

2025

2026

hybridLicense: cc-by-nc-nd

journalhttps://www.pnas.org/doi/pdf/10.1073/pnas.2311313121

publisherhttps://www.pnas.org/doi/pdf/10.1073/pnas.2311313121

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2311313121

journalhttps://doi.org/10.1073/pnas.2311313121

repositoryhttps://pubmed.ncbi.nlm.nih.gov/38241436

Fields of Study

Genetics, Aging, and Longevity in Model Organisms0303 health sciences03 medical and health sciencesAnimalsMaleHumansFemaleAgedDrosophilaDrosophila melanogasterAgingStem CellsMammalsPyridonesPyrimidinones

MeSH Terms

AgedAgingAnimalsDrosophilaDrosophila melanogasterFemaleHumansMaleMammalsPyridonesPyrimidinonesStem Cells

Keywords

TrametinibBiologyMAPK/ERK pathwayCell biologyDrosophila melanogasterKinaseCancer researchGeneticsGeneAgingDrosophilaPol IiiGut PathologyMaleMammalsPyridonesStem CellsPyrimidinonesBiological SciencesAnimalsHumansFemaleAged

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being