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A classic antibiotic reimagined: Rationally designed bacitracin variants exhibit potent activity against vancomycin-resistant pathogens

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2315310121Source: DataRank Database

A classic antibiotic reimagined: Rationally designed bacitracin variants exhibit potent activity against vancomycin-resistant pathogens is a research paper published in Proceedings of the National Academy of Sciences (2024). On theSindex it has a DataRank of 0. It has been cited 25 times.

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0DataRank · unranked

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Open Access25 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (4 grants)Impact (FWCI 8.76)OA: hybridTopics (52)IDs (PubMed, PMC, OpenAlex)Annotations (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (10)

Halana C. Vlaming ORCID,Ioli Kotsogianni ORCID,Melina Arts ORCID,Joost Willemse ORCID,Y. P. Duan ORCID

Live enrichment

PubMed:38990944 PMC:PMC11260088 OpenAlex:https://openalex.org/W4400526186

EC | European Research Council

Grant: 725523

Addressing Antibiotic Resistance: New Strategies for Overcoming the ESKAPE Pathogens

UKRI | Engineering and Physical Sciences Research Council

Grant: EP/V032860/1

Interrogating the Nisin:lipid II Interaction: A Chemical Biology Approach

Deutsche Forschungsgemeinschaft

Grant: 398967434

Deutsche Forschungsgemeinschaft

Grant: unidentified

unidentified

FWCI

8.76

Citation Percentile

1.0%

Citation Trend

2024

2025

2026

hybridLicense: cc-by-nc-nd

journalhttps://www.pnas.org/doi/pdf/10.1073/pnas.2315310121

publisherhttps://www.pnas.org/doi/pdf/10.1073/pnas.2315310121

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2315310121

journalhttps://doi.org/10.1073/pnas.2315310121

repositoryhttps://pubmed.ncbi.nlm.nih.gov/38990944

Fields of Study

Microbial Natural Products and BiosynthesisNatural product bioactivities and synthesisMarine Sponges and Natural Products0301 basic medicine0303 health sciences03 medical and health sciencesAnti-Bacterial AgentsBacitracinMicrobial Sensitivity TestsStructure-Activity RelationshipDrug Resistance, BacterialVancomycinDrug DesignPolyisoprenyl Phosphates

MeSH Terms

Anti-Bacterial AgentsBacitracinMicrobial Sensitivity TestsPolyisoprenyl PhosphatesStructure-Activity RelationshipVancomycinDrug DesignDrug Resistance, Bacterial

Keywords

BacitracinLipid IIAntibioticsAntibacterial activityBacteriaBacterial cell structureChemistryGlycopeptidePeptideBiochemistryMicrobiologyBiologyPeptidoglycanCell wallNatural productsAntibiotic ResistanceC55pp BindingCPP bindingMicrobial Sensitivity TestsBiological Sciences540/dk/atira/pure/subjectarea/asjc/1000; name=GeneralAnti-Bacterial AgentsStructure-Activity Relationshipname=GeneralPolyisoprenyl PhosphatesVancomycinDrug Design/dk/atira/pure/subjectarea/asjc/1000Drug Resistance, Bacterial

A classic antibiotic reimagined: Rationally designed bacitracin variants exhibit potent activity against vancomycin-resistant pathogens

FAIR Checklist

Authors (10)

Funding (4 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)