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A TLR4/TRAF6-dependent signaling pathway mediates NCoR coactivator complex formation for inflammatory gene activation

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2316104121Source: DataRank Database

A TLR4/TRAF6-dependent signaling pathway mediates NCoR coactivator complex formation for inflammatory gene activation is a research paper published in Proceedings of the National Academy of Sciences (2024). On theSindex it has a DataRank of 0.578. It has been cited 18 times, with 14 citing works in its 1-hop citation network.

N/A

0.578DataRank · unranked

Scored on demand from live citation data

Open Access18 citations · 14 citing works in its network

Cite:

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (25 grants)OA: hybridTopics (45)IDs (PubMed)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 76%Citation Network 24%

Base Score Contribution

0.442

From this paper's citation signal

Citation Network Contribution

0.136

From 9 citing papers with measurable signal

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Authors (20)

Eric R. Kofman,Zhengyu Ouyang,Grisel Cruz-Becerra,Nathanael J. Spann ORCID,Jason S. Seidman ORCID

Live enrichment

PubMed:38165941

Foundation for the National Institutes of Health

Grant: DK091183

Foundation for the National Institutes of Health

Grant: HL088093

Foundation for the National Institutes of Health

Grant: DK063491

Foundation for the National Institutes of Health

Grant: GM118060

Fondation Leducq

Grant: 16CVD01

Foundation for the National Institutes of Health

Grant: GM085764

Foundation for the National Institutes of Health

Grant: OD026929

MEXT | Japan Society for the Promotion of Science

Grant: 201860150

National Science Foundation

Grant: DGE-2038238

National Institutes of Health

Grant: 3P30DK063491-04S1

Diabetes Endocrinology Research Center

National Science Foundation

Grant: 2038238

Graduate Research Fellowship Program (GRFP)

National Institutes of Health

Grant: 1S10OD026929-01

Illumina NovaSeq 6000 Sequencing System

National Institutes of Health

Grant: 3P01HL088093-04S1

Program Project: Role of Innate Immunity in Atherosclerosis

National Institutes of Health

Grant: 5R35GM118060-02

Mechanisms of Eukaryotic Gene Regulation

National Institutes of Health

Grant: 5R01DK091183-34

Transcriptional co-regulators and macrophage gene expression

National Institutes of Health

Grant: 3P50GM085764-03S1

Center for Systems Biology of Cellular Stress Responses

NHLBI NIH HHS

Grant: P01 HL088093

NIGMS NIH HHS

Grant: R35 GM118060

NIDDK NIH HHS

Grant: R01 DK091183

NIDDK NIH HHS

Grant: P30 DK063491

NIH HHS

Grant: S10 OD026929

NIDDK NIH HHS

Grant: R01 DK039949

NCI NIH HHS

Grant: P30 CA014195

NHLBI NIH HHS

Grant: P01 HL147835

NIGMS NIH HHS

Grant: P50 GM085764

hybridLicense: cc-by

publisherhttps://www.pnas.org/doi/pdf/10.1073/pnas.2316104121

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2316104121

repositoryhttps://escholarship.org/content/qt2hq3j4sc/qt2hq3j4sc.pdf

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC10786282/pdf/pnas.202316104.pdf

https://doi.org/10.1073/pnas.2316104121

Fields of Study

0301 basic medicine03 medical and health sciences0303 health sciencesTranscriptional ActivationCo-Repressor ProteinsHistonesTNF Receptor-Associated Factor 6Transcription Factor AP-1Toll-Like Receptor 4Signal TransductionNF-kappa BReceptors, Cytoplasmic and Nuclear

MeSH Terms

Transcriptional ActivationCo-Repressor ProteinsHistonesTNF Receptor-Associated Factor 6Transcription Factor AP-1Toll-Like Receptor 4Signal TransductionNF-kappa BReceptors, Cytoplasmic and Nuclear

Keywords

Transcriptional ActivationCytoplasmic and Nuclear1.1 Normal biological development and functioning610Receptors, Cytoplasmic and NuclearmacrophageHistonesPGC1βReceptorsGenetics2.1 Biological and endogenous factorsTLR4PGC1 betaTNF Receptor-Associated Factor 6Inflammatory and immune systemNF-kappa BBiological SciencesTranscription Factor AP-1Toll-Like Receptor 4NCoRBiochemistry and Cell BiologyCo-Repressor ProteinsTRAF6Signal Transduction

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