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Huntingtin contains an ubiquitin-binding domain and regulates lysosomal targeting of mitochondrial and RNA-binding proteins

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2319091121Source: DataRank Database

Huntingtin contains an ubiquitin-binding domain and regulates lysosomal targeting of mitochondrial and RNA-binding proteins is a research paper published in Proceedings of the National Academy of Sciences (2024). On theSindex it has a DataRank of 0. It has been cited 9 times.

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Open Access9 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (27 grants)Impact (FWCI 1.68)OA: hybridTopics (77)IDs (PubMed, PMC, OpenAlex)Annotations (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (21)

Vinay V. Eapen ORCID,Ryan G. Lim ORCID,Clinton Yu ORCID,Lisa Salazar,Nicolette R. McClure

Live enrichment

PubMed:39074279 PMC:PMC11317567 OpenAlex:https://openalex.org/W4401071062

HHS | NIH | NIH Blueprint for Neuroscience Research

Grant: NS072453

HHS | NIH | National Institute on Aging

Grant: 1F30AG060704-01A1

Defining the Function of APOE in Autophagy and Neurodegeneration

HHS | NIH | National Institute of General Medical Sciences

Grant: T32GM008620

HHS | NIH | National Institute on Aging

Grant: T32AG000096

HHS | NIH | NIH Blueprint for Neuroscience Research

Grant: NS091046-01

HHS | NIH | NIH Blueprint for Neuroscience Research

Grant: NS052789

HHS | NIH | National Institute of Neurological Disorders and Stroke

Grant: NS090390

HHS | NIH | NIH Blueprint for Neuroscience Research

Grant: NS116872

HHS | NIH | NIH Blueprint for Neuroscience Research

Grant: R35NS116872

HHS | NIH | National Institute of General Medical Sciences

Grant: R35GM148350

HHS | NIH | National Institute of General Medical Sciences

Grant: R35GM145249

HHS | NIH | NIH Blueprint for Neuroscience Research

Grant: NSR37101996

NIA NIH HHS

Grant: F30 AG060704

NINDS NIH HHS

Grant: R37 NS101996

NINDS NIH HHS

Grant: U54 NS091046

NINDS NIH HHS

Grant: R01 NS089076

NINDS NIH HHS

Grant: R56 NS090390

NINDS NIH HHS

Grant: R01 NS090390

NINDS NIH HHS

Grant: R56 NS072453

NINDS NIH HHS

Grant: R01 NS052789

NINDS NIH HHS

Grant: R01 NS072453

National Institutes of Health

Grant: 5R01NS090390-04

Neuroregulatory Mechanisms of PIAS1 and Implications for Huntington's Disease

National Institutes of Health

Grant: 3R35GM148350-02S2

Ubiquitin and Metabolite Signaling

National Institutes of Health

Grant: 5R35NS116872-05

Molecular Mechanisms of Pathogenesis in Huntington’s disease

National Institutes of Health

Grant: 5T32GM008620-23

Medical Scientist Training Program

National Institutes of Health

Grant: 1R35GM145249-01

Advancing Proteomics Technologies to Decipher the Ubiquitin-Proteasome System

National Institutes of Health

Grant: 5T32AG000096-12

TRAINING IN THE NEUROBIOLOGY OF AGING

FWCI

1.68

Citation Percentile

0.8%

Citation Trend

2024

2025

2026

hybridLicense: cc-by

journalhttps://www.pnas.org/doi/pdf/10.1073/pnas.2319091121

HYBRIDhttps://www.pnas.org/doi/pdf/10.1073/pnas.2319091121

publisherhttps://www.pnas.org/doi/pdf/10.1073/pnas.2319091121

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2319091121

journalhttps://doi.org/10.1073/pnas.2319091121

Fields of Study

Genetic Neurodegenerative DiseasesMitochondrial Function and PathologyAutophagy in Disease and TherapyMedicineBiology0301 basic medicine03 medical and health sciences0303 health sciencesHuntingtin ProteinLysosomesRNA-Binding ProteinsHumansUbiquitinMitochondriaAutophagyAnimalsMitochondrial ProteinsMiceProtein BindingHuntington DiseasePeptides

MeSH Terms

Huntingtin ProteinAnimalsAutophagyHumansHuntington DiseaseLysosomesMitochondriaPeptidesProtein BindingRNA-Binding ProteinsMitochondrial ProteinsUbiquitinMice

Keywords

HuntingtinCell biologyUbiquitinRNA-binding proteinLysosomeBiologyProteomeAutophagyNeurodegenerationRNAChemistryBiochemistryGeneMutantApoptosisRNA-binding proteinsUbiquitin-binding DomainHuntington's Disease570ubiquitin- binding domain1.1 Normal biological development and functioning610NeurodegenerativeMitochondrial ProteinsMiceRare DiseasesRNA- binding proteinsGenetics2.1 Biological and endogenous factorsHumansAnimalsHuntingtin ProteinNeurosciencesBiological SciencesBrain DisordersMitochondriaOrphan DrugHuntington DiseaseNeurologicalBiochemistry and Cell BiologyLysosomesPeptidesProtein Binding

Huntingtin contains an ubiquitin-binding domain and regulates lysosomal targeting of mitochondrial and RNA-binding proteins

FAIR Checklist

Authors (21)

Funding (27 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)