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Asymmetric allostery in estrogen receptor-α homodimers drives responses to the ensemble of estrogens in the hormonal milieu

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2321344121Source: DataRank Database

Asymmetric allostery in estrogen receptor-α homodimers drives responses to the ensemble of estrogens in the hormonal milieu is a research paper published in Proceedings of the National Academy of Sciences (2024). On theSindex it has a DataRank of 0. It has been cited 7 times.

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Open Access7 citations

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Enrichment:Funding (4 grants)Impact (FWCI 2.72)OA: hybridTopics (32)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (14)

J.C. Nwachukwu ORCID,Yingwei Hou ORCID,Robin Russo,Alexandra Papa,Jian Min ORCID

Live enrichment

PubMed:38830107 PMC:PMC11181081 OpenAlex:https://openalex.org/W4399304571

HHS | NIH | National Cancer Institute

Grant: R01CA275142

HHS | NIH | National Cancer Institute

Grant: R01CA220284

Breast Cancer Research Foundation

Grant: BCRF-083 BCRF-084

NIGMS NIH HHS

Grant: R35 GM139604

FWCI

2.72

Citation Percentile

0.9%

Citation Trend

2024

2025

2026

hybridLicense: cc-by-nc-nd

journalhttps://www.pnas.org/doi/pdf/10.1073/pnas.2321344121

publisherhttps://www.pnas.org/doi/pdf/10.1073/pnas.2321344121

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2321344121

journalhttps://doi.org/10.1073/pnas.2321344121

repositoryhttps://pubmed.ncbi.nlm.nih.gov/38830107

Fields of Study

Estrogen and related hormone effectsComputational Drug Discovery MethodsBioactive Compounds and Antitumor Agents

MeSH Terms

Allosteric RegulationBinding SitesEstrogensHumansLigandsProtein BindingProtein ConformationEstrogen Receptor alphaProtein MultimerizationMolecular Dynamics Simulation

Keywords

Allosteric regulationLigand (biochemistry)DimerChemistryEstrogen receptorAllosteric enzymeAgonistConformational isomerismBinding siteReceptorStereochemistryBiophysicsCooperative bindingEstrogen receptor betaBiochemistryBiologyMoleculeX-ray crystallographyMolecular Dynamics Simulations

Sustainable Development Goals

SDG 0: Life in Land

Asymmetric allostery in estrogen receptor-α homodimers drives responses to the ensemble of estrogens in the hormonal milieu

FAIR Checklist

Authors (14)

Funding (4 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)