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Dynamically adjusted cell fate decisions and resilience to mutant invasion during steady-state hematopoiesis revealed by an experimentally parameterized mathematical model

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2321525121Source: DataRank Database

Dynamically adjusted cell fate decisions and resilience to mutant invasion during steady-state hematopoiesis revealed by an experimentally parameterized mathematical model is a research paper published in Proceedings of the National Academy of Sciences (2024). On theSindex it has a DataRank of 0. It has been cited 4 times.

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Open Access4 citations

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Enrichment:Funding (3 grants)Impact (FWCI 1.45)OA: hybridTopics (53)IDs (PubMed, PMC, OpenAlex)Annotations (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (4)

Chiara Rignot,Angela G. Fleischman ORCID,Dominik Wodarz ORCID,Natalia L. Komarova ORCID

Live enrichment

PubMed:39250660 PMC:PMC11420203 OpenAlex:https://openalex.org/W4402349712

HHS | NIH

Grant: R37CA271172

NSF

Grant: DMS 2152155

NCI NIH HHS

Grant: P30 CA062203

FWCI

1.45

Citation Percentile

0.8%

Citation Trend

2025

2026

hybridLicense: cc-by-nc-nd

journalhttps://www.pnas.org/doi/pdf/10.1073/pnas.2321525121

publisherhttps://www.pnas.org/doi/pdf/10.1073/pnas.2321525121

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2321525121

journalhttps://doi.org/10.1073/pnas.2321525121

repositoryhttps://pubmed.ncbi.nlm.nih.gov/39250660

Fields of Study

Hematopoietic Stem Cell TransplantationSingle-cell and spatial transcriptomicsEvolution and Genetic DynamicsAnimalsHematopoietic Stem CellsMiceHematopoiesisCell DifferentiationMutationDNA Methyltransferase 3AHomeostasisDNA (Cytosine-5-)-MethyltransferasesModels, BiologicalCell LineageDioxygenasesDNA-Binding ProteinsClonal EvolutionModels, Theoretical

MeSH Terms

DNA Methyltransferase 3AAnimalsCell DifferentiationDNA (Cytosine-5-)-MethyltransferasesDNA-Binding ProteinsHematopoiesisHematopoietic Stem CellsHomeostasisModels, BiologicalModels, TheoreticalMutationCell LineageDioxygenasesMiceClonal Evolution

Keywords

BiologyHaematopoiesisCell biologyStem cellNicheProgenitor cellMutantParameterized complexityHematopoietic stem cellProcess (computing)Cell fate determinationSystems biologyComputational biologyComputer scienceGeneticsEcologyMathematical modelsHematopoietic stem cellsEvolutionary DynamicsClonal Hematopoiesis

Dynamically adjusted cell fate decisions and resilience to mutant invasion during steady-state hematopoiesis revealed by an experimentally parameterized mathematical model

FAIR Checklist

Authors (4)

Funding (3 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)