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UPF1 deficiency enhances mitochondrial ROS which promotes an immunosuppressive microenvironment in pancreatic ductal adenocarcinoma

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2401996121Source: DataRank Database

UPF1 deficiency enhances mitochondrial ROS which promotes an immunosuppressive microenvironment in pancreatic ductal adenocarcinoma is a research paper published in Proceedings of the National Academy of Sciences (2024). On theSindex it has a DataRank of 0. It has been cited 3 times.

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Open Access3 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (5 grants)Impact (FWCI 0.47)OA: hybridTopics (58)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (10)

Juan Andres Kochen Rossi ORCID,Cristina Nuevo‐Tapioles ORCID,Ting Chen ORCID,Emily Kawaler ORCID,Cristina Branco ORCID

Live enrichment

PubMed:40591563 PMC:PMC11331118 OpenAlex:https://openalex.org/W4401358583

HHS | National Institutes of Health

Grant: R01CA211687 R35CA253178

HHS | National Institutes of Health

Grant: F31CA261120

National Institutes of Health

Grant: 5R35CA253178-04

Differential function and tumor vulnerabilities revealed by RAS membrane trafficking

National Institutes of Health

Grant: 5R01CA211687-03

Role of nonsense mediated RNA decay in pancreatic cancer

National Institutes of Health

Grant: 5F31CA261120-02

Characterization of the PKM2-RAS Interaction as a Novel Metabolic Vulnerability of RAS-driven Tumors

FWCI

0.47

Citation Percentile

0.6%

Citation Trend

2025

2026

hybridLicense: cc-by-nc-nd

journalhttps://www.pnas.org/doi/pdf/10.1073/pnas.2401996121

publisherhttps://www.pnas.org/doi/pdf/10.1073/pnas.2401996121

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2401996121

journalhttps://doi.org/10.1073/pnas.2401996121

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40591563

Fields of Study

RNA modifications and cancerCancer, Hypoxia, and MetabolismATP Synthase and ATPases Research0301 basic medicine0303 health sciences03 medical and health sciencesAnimalsCarcinoma, Pancreatic DuctalMiceMitochondriaTumor MicroenvironmentRNA HelicasesReactive Oxygen SpeciesTrans-ActivatorsPancreatic NeoplasmsMice, Inbred C57BLHumansCell Line, Tumor

MeSH Terms

AnimalsHumansMice, Inbred C57BLMitochondriaPancreatic NeoplasmsTrans-ActivatorsReactive Oxygen SpeciesRNA HelicasesCarcinoma, Pancreatic DuctalCell Line, TumorMiceTumor Microenvironment

Keywords

Pancreatic ductal adenocarcinomaCancer researchTumor microenvironmentPancreatic carcinomaMitochondrionMitochondrial ROSMedicinePancreatic cancerBiologyInternal medicineCell biologyCancerTumor cellsComplex IMyeloid-derived Suppressor CellsUpf1Biological SciencesMitochondriaPancreatic NeoplasmsMice, Inbred C57BLMiceCell Line, TumorTrans-ActivatorsAnimalsHumansReactive Oxygen SpeciesRNA HelicasesCarcinoma, Pancreatic Ductal

Sustainable Development Goals

SDG 3: 3. Good health

UPF1 deficiency enhances mitochondrial ROS which promotes an immunosuppressive microenvironment in pancreatic ductal adenocarcinoma

FAIR Checklist

Authors (10)

Funding (5 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)