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Hydroxychloroquine prevents resistance and potentiates the antitumor effect of SHP2 inhibition in NF1-associated malignant peripheral nerve sheath tumors

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2407745121Source: DataRank Database

Hydroxychloroquine prevents resistance and potentiates the antitumor effect of SHP2 inhibition in NF1-associated malignant peripheral nerve sheath tumors is a research paper published in Proceedings of the National Academy of Sciences (2024). On theSindex it has a DataRank of 0.351. It has been cited 7 times, with 6 citing works in its 1-hop citation network.

N/A

0.351DataRank · unranked

Scored on demand from live citation data

Open Access7 citations · 6 citing works in its network

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Linked data & code

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DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (7 grants)Impact (FWCI 1.88)OA: hybridTopics (35)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 89%Citation Network 11%

Base Score Contribution

0.312

From this paper's citation signal

Citation Network Contribution

0.0394

From 5 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 6 citers.

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Personalized pharmacokinetic–pharmacodynamic guided therapy via an induced pluripotent stem cell–derived multi-organoid platform in NF1-mutant breast cancer
Signal Transduction and Targeted Therapy20261 citations46 referencesContributes 0.015
Advances in Computational Drug Repurposing, Driver Genes, and Therapeutics in Lung Adenocarcinoma
Biomolecules20252 citations162 referencesContributes 0.007
Targeting the MAPK Pathway in Brain Tumors: Mechanisms and Therapeutic Opportunities
Cancers20261 citations188 referencesContributes 0.004
Autophagy modulation in cancer
Nature Reviews Drug Discovery20262 citations355 referencesContributes 0.003

Authors (16)

Kwan Ho Tang ORCID,Steven P. Angus ORCID,Rebecca Brown ORCID,Daochun Sun ORCID,Xuanhua Xie ORCID

Live enrichment

PubMed:39793045 PMC:PMC11725864 OpenAlex:https://openalex.org/W4405909578

HHS | National Institutes of Health

Grant: P30 CA008748

HHS | National Institutes of Health

Grant: P30 CA016087

HHS | National Institutes of Health

Grant: U54 CA196519

DOD | USA | MEDCOM | Congressionally Directed Medical Research Programs

Grant: W81XWH-16-1-0186

HHS | National Institutes of Health

Grant: R01CA131313

NCI NIH HHS

Grant: R01 CA049152

NCI NIH HHS

Grant: R37 CA049152

FWCI

1.88

Citation Percentile

0.9%

Citation Trend

2025

2026

hybridLicense: cc-by-nc-nd

journalhttps://doi.org/10.1073/pnas.2407745121

publisherhttps://doi.org/10.1073/pnas.2407745121

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2407745121

repositoryhttps://pubmed.ncbi.nlm.nih.gov/39793045

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/11725864

Fields of Study

Neurofibromatosis and Schwannoma CasesProtein Tyrosine PhosphatasesSarcoma Diagnosis and Treatment

MeSH Terms

AnimalsDrug SynergismHumansHydroxychloroquineNeurofibromatosis 1Signal TransductionNerve Sheath NeoplasmsDrug Resistance, NeoplasmXenograft Model Antitumor AssaysNeurofibromin 1Cell Line, TumorMiceProtein Tyrosine Phosphatase, Non-Receptor Type 11

Keywords

NeurofibromatosisCancer researchMedicineProtein tyrosine phosphataseNeurofibromin 1Nerve sheath neoplasmMalignant peripheral nerve sheath tumorTrametinibSignal transductionPathologyMAPK/ERK pathwayBiologyInternal medicineReceptorAutophagyHydroxychloroquineNf1MpnstShp2 Inhibition

Sustainable Development Goals

SDG 0: Good health and well-being

Hydroxychloroquine prevents resistance and potentiates the antitumor effect of SHP2 inhibition in NF1-associated malignant peripheral nerve sheath tumors

FAIR Checklist

DataRank Breakdown

Top 5 citers driving the network score

Authors (16)

Funding (7 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)