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Targeting the muscarinic M1 receptor with a selective, brain-penetrant antagonist to promote remyelination in multiple sclerosis

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2407974121Source: DataRank Database

Targeting the muscarinic M1 receptor with a selective, brain-penetrant antagonist to promote remyelination in multiple sclerosis is a research paper published in Proceedings of the National Academy of Sciences (2024). On theSindex it has a DataRank of 0. It has been cited 37 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access37 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (5 grants)Impact (FWCI 11.19)OA: hybridTopics (75)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (13)

Kym I. Lorrain,Karin J. Stebbins,Geraldine C. Edu,Alexander Broadhead,Ariana Joy Orduna Lorenzana

Live enrichment

PubMed:39083422 PMC:PMC11317586 OpenAlex:https://openalex.org/W4401171105

HHS | NIH | National Institute of Neurological Disorders and Stroke

Grant: R01NS115746

HHS | NIH | National Institute of Mental Health

Grant: R01MH125515

Dr. Miriam and Sheldon G. Adelson Medical Research Foundation

Grant: A130141

National Institutes of Health

Grant: 5R01MH125515-04

Cell-type, circuit and network mechanisms of adult oligodendrogenesis in memory storage and retrieval

National Institutes of Health

Grant: 1R01NS115746-01A1

Neuropeptides as axonal determinants for oligodendrocyte differentiation and myelination

FWCI

11.19

Citation Percentile

1.0%

Citation Trend

2024

2025

2026

hybridLicense: cc-by

journalhttps://www.pnas.org/doi/pdf/10.1073/pnas.2407974121

publisherhttps://www.pnas.org/doi/pdf/10.1073/pnas.2407974121

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2407974121

journalhttps://doi.org/10.1073/pnas.2407974121

repositoryhttps://pubmed.ncbi.nlm.nih.gov/39083422

Fields of Study

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration Mechanisms0301 basic medicine03 medical and health sciences0303 health sciencesAnimalsHumansMiceRatsBrainEncephalomyelitis, Autoimmune, ExperimentalMice, Inbred C57BLMultiple SclerosisMuscarinic AntagonistsMyelin SheathOligodendrogliaReceptor, Muscarinic M1Remyelination

MeSH Terms

RemyelinationAnimalsBrainEncephalomyelitis, Autoimmune, ExperimentalFemaleHumansMice, Inbred C57BLMultiple SclerosisMyelin SheathOligodendrogliaMuscarinic AntagonistsReceptor, Muscarinic M1MiceRats

Keywords

RemyelinationNeuroscienceMultiple sclerosisMedicineChemistryBiologyMyelinCentral nervous systemImmunologymuscarinic receptorsoligodendrocyteMyelinationEncephalomyelitis, Autoimmune, Experimental1.1 Normal biological development and functioning610Muscarinic AntagonistsNeurodegenerativeInbred C57BLAutoimmune DiseaseExperimentalMiceAnimalsHumans|muscarinic receptorsEncephalomyelitisMyelin SheathBiomedical and Clinical SciencesReceptor, Muscarinic M1NeurosciencesBrainPharmacology and Pharmaceutical SciencesBiological SciencesBrain DisordersRatsMice, Inbred C57BLOligodendroglia5.1 PharmaceuticalsMuscarinic M1Chemical SciencesNeurologicalAutoimmuneReceptor

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being