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Agonist activation to open the Gα subunit of the GPCR–G protein precoupled complex defines functional agonist activation of TAS2R5

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2409987121Source: DataRank Database

Agonist activation to open the Gα subunit of the GPCR–G protein precoupled complex defines functional agonist activation of TAS2R5 is a research paper published in Proceedings of the National Academy of Sciences (2024). On theSindex it has a DataRank of 0. It has been cited 8 times.

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Open Access8 citations

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Enrichment:Funding (3 grants)Impact (FWCI 1.28)OA: hybridTopics (40)IDs (PubMed, PMC, OpenAlex)Annotations (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (9)

Khuong Duy Mac ORCID,Hannah R. Strzelinski ORCID,Sandy J. Hoffman,Donghwa Kim ORCID,Soo-Kyung Kim ORCID

Live enrichment

PubMed:39565310 PMC:PMC11621838 OpenAlex:https://openalex.org/W4404533729

HHS | NIH

Grant: R01HL155532

HHS | NIH

Grant: R35GM137988

NHLBI NIH HHS

Grant: P01 HL114471

FWCI

1.28

Citation Percentile

0.8%

Citation Trend

2025

2026

hybridLicense: cc-by-nc-nd

journalhttps://www.pnas.org/doi/pdf/10.1073/pnas.2409987121

publisherhttps://www.pnas.org/doi/pdf/10.1073/pnas.2409987121

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2409987121

journalhttps://doi.org/10.1073/pnas.2409987121

repositoryhttps://pubmed.ncbi.nlm.nih.gov/39565310

Fields of Study

Receptor Mechanisms and SignalingBiochemical Analysis and Sensing TechniquesNeuropeptides and Animal PhysiologyReceptors, G-Protein-CoupledHumansMolecular Dynamics SimulationGTP-Binding Protein alpha SubunitsHEK293 CellsSignal TransductionProtein BindingLigandsTaste Receptors, Type 2

MeSH Terms

Taste Receptors, Type 2HumansLigandsProtein BindingSignal TransductionReceptors, G-Protein-CoupledGTP-Binding Protein alpha SubunitsMolecular Dynamics SimulationHEK293 Cells

Keywords

G protein-coupled receptorAgonistG proteinMetadynamicsSignal transductionReceptorChemistryBiophysicsFunctional selectivityLigand (biochemistry)Intrinsic activityProtein subunitBiochemistryBiologyMolecular dynamicsComputational chemistryFlowerAirway smooth muscleBitter Taste Receptor

Agonist activation to open the Gα subunit of the GPCR–G protein precoupled complex defines functional agonist activation of TAS2R5

FAIR Checklist

Authors (9)

Funding (3 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)