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Cryo-EM heterogeneity analysis using regularized covariance estimation and kernel regression

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2419140122Source: DataRank Database

Cryo-EM heterogeneity analysis using regularized covariance estimation and kernel regression is a research paper published in Proceedings of the National Academy of Sciences (2025). On theSindex it has a DataRank of 0. It has been cited 20 times.

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Open Access20 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (9 grants)Impact (FWCI 19.46)OA: hybridTopics (41)IDs (PubMed, PMC, OpenAlex)Annotations (3)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (2)

Amit Singer ORCID,Marc Aurèle Gilles ORCID

Live enrichment

PubMed:40009640 PMC:PMC11892586 OpenAlex:https://openalex.org/W4407950139

DOD | AF | AMC | AFRL | Air Force Office of Scientific Research

Grant: FA9550-23-1-0249

Simons Foundation

Grant: Math+X Investigator Award

National Science Foundation

Grant: DMS-2009753

HHS | National Institutes of Health

Grant: R01GM136780-01

National Science Foundation

Grant: DMS- 1925919

NIGMS NIH HHS

Grant: R01 GM136780

National Science Foundation

Grant: 1925919

Institute for Pure and Applied Mathematics

National Institutes of Health

Grant: 5R01GM136780-04

Reconstruction of heterogeneous and small macromolecules by cyro-EM

National Science Foundation

Grant: 2009753

NSF-BSF: Modern Techniques for Signal Reconstruction from Moments

FWCI

19.46

Citation Percentile

1.0%

Citation Trend

2024

2025

2026

hybridLicense: cc-by-nc-nd

journalhttps://doi.org/10.1073/pnas.2419140122

publisherhttps://doi.org/10.1073/pnas.2419140122

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2419140122

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40009640

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/11892586

Fields of Study

Advanced Electron Microscopy Techniques and ApplicationsElectron and X-Ray Spectroscopy TechniquesMachine Learning in Materials Science0206 medical engineering02 engineering and technologyCryoelectron MicroscopyPrincipal Component AnalysisAlgorithmsImage Processing, Computer-AssistedProtein Conformation

MeSH Terms

AlgorithmsImage Processing, Computer-AssistedProtein ConformationCryoelectron MicroscopyPrincipal Component Analysis

Keywords

InterpretabilityComputer scienceKernel (algebra)Principal component analysisCovarianceAlgorithmRegularization (linguistics)EmbeddingArtificial intelligencePattern recognition (psychology)Covariance matrixCanonical correlationKernel density estimationEstimatorMathematicsStatisticsDensity estimationCovariance EstimationCryogenic Electron MicroscopyHeterogeneity AnalysisProtein ConformationPhysical SciencesCryoelectron MicroscopyImage Processing, Computer-AssistedArticleAlgorithms

Sustainable Development Goals

SDG 0: Affordable and clean energy

Cryo-EM heterogeneity analysis using regularized covariance estimation and kernel regression

FAIR Checklist

Authors (2)

Funding (9 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)