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pTDP-43 levels correlate with cell type–specific molecular alterations in the prefrontal cortex of C9orf72 ALS/FTD patients

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2419818122Source: DataRank Database

pTDP-43 levels correlate with cell type–specific molecular alterations in the prefrontal cortex of C9orf72 ALS/FTD patients is a research paper published in Proceedings of the National Academy of Sciences (2025). On theSindex it has a DataRank of 0. It has been cited 6 times.

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Open Access6 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (10 grants)Impact (FWCI 4.06)OA: hybridTopics (62)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (13)

Jian‐Feng Xiang ORCID,Chenyang Yuan ORCID,Austin M. Veire ORCID,Tania F. Gendron ORCID,Melissa E. Murray ORCID

Live enrichment

PubMed:39999167 PMC:PMC11892677 OpenAlex:https://openalex.org/W4407938812

HHS | NIH | National Institute of General Medical Sciences

Grant: R35 GM139408

HHS | NIH | National Institute of Neurological Disorders and Stroke

Grant: R35 NS111602

HHS | NIH | National Institute of Environmental Health Sciences

Grant: F32 ES031827

NHGRI NIH HHS

Grant: RM1 HG008935

NIMH NIH HHS

Grant: U01 MH116441

National Institutes of Health

Grant: 1P30ES019776-01A1

HERCULES: Health and Exposome Research Center at Emory

National Institutes of Health

Grant: 1U01MH116441-01

Dynamic RNA Modifications in human brain development and autism

National Institutes of Health

Grant: 5F32ES031827-02

Mechanisms of bisphenol A induced epigenomic alterations in the mammalian germline

National Institutes of Health

Grant: 2R01ES027859-06A1

Mechanisms of transgenerational epigenetic inheritance

National Institutes of Health

Grant: 5R35NS111602-04

Dynamic DNA Modifications in Brain and Diseases

FWCI

4.06

Citation Percentile

0.9%

Citation Trend

2025

2026

hybridLicense: cc-by-nc-nd

journalhttps://www.pnas.org/doi/pdf/10.1073/pnas.2419818122

publisherhttps://www.pnas.org/doi/pdf/10.1073/pnas.2419818122

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2419818122

journalhttps://doi.org/10.1073/pnas.2419818122

repositoryhttps://pubmed.ncbi.nlm.nih.gov/39999167

Fields of Study

Amyotrophic Lateral Sclerosis ResearchNeuroinflammation and Neurodegeneration MechanismsParkinson's Disease Mechanisms and Treatments0301 basic medicine0303 health sciences03 medical and health sciencesHumansAmyotrophic Lateral SclerosisC9orf72 ProteinPrefrontal CortexFrontotemporal DementiaMaleDNA-Binding ProteinsFemaleMiddle AgedMicrogliaAgedPhosphorylationNeurons

MeSH Terms

C9orf72 ProteinAgedAmyotrophic Lateral SclerosisDNA-Binding ProteinsFemaleHumansMaleMiddle AgedNeuronsPhosphorylationPrefrontal CortexMicrogliaDNA Repeat ExpansionFrontotemporal Dementia

Keywords

C9orf72MicrogliaBiologyFrontotemporal dementiaPrefrontal cortexNeuroscienceCortex (anatomy)Cerebral cortexAmyotrophic lateral sclerosisPathologyDementiaDiseaseInflammationImmunologyMedicineNeurodegenerationEpigeneticschromatinMaleNeuronsC9orf72 ProteinBiological SciencesMiddle AgedArticleDNA-Binding ProteinsHumansFemalePhosphorylationAged

Sustainable Development Goals

SDG 0: Good health and well-being

pTDP-43 levels correlate with cell type–specific molecular alterations in the prefrontal cortex of C9orf72 ALS/FTD patients

FAIR Checklist

Authors (13)

Funding (10 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)