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CRISPR screens and quantitative proteomics reveal remodeling of the aryl hydrocarbon receptor–driven proteome through PARP7 activity

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2424985122Source: DataRank Database

CRISPR screens and quantitative proteomics reveal remodeling of the aryl hydrocarbon receptor–driven proteome through PARP7 activity is a research paper published in Proceedings of the National Academy of Sciences (2025). On theSindex it has a DataRank of 0. It has been cited 8 times.

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Enrichment:Funding (18 grants)Impact (FWCI 3.73)OA: hybridTopics (57)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

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Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (14)

Joao A. Paulo ORCID,Christina B. Schroeter ORCID,Melanie Lad,Abigail Shurr,Chara Mastrokalou

Live enrichment

PubMed:40493189 PMC:PMC12184497 OpenAlex:https://openalex.org/W4411178697

Wellcome Trust

Grant: 224095/Z/21/Z

Wellcome Trust

Grant: 210634 223107 302632

UKRI | Biotechnology and Biological Sciences Research Council

Grant: BB/R007195/1 BB/W016613/1

Cancer Research UK

Grant: C35050/A22284

HHS | NIH

Grant: GM67945

HHS | NIH

Grant: GM132129

Wellcome Trust

Grant: 210634

Serine ADP-ribosylation in genome stability and human disease

NIGMS NIH HHS

Grant: R01 GM132129

Wellcome Trust

Grant: 223107

Reversible ADP-ribosylation signaling in the control of coronavirus infection

Biotechnology and Biological Sciences Research Council

Grant: BB/R007195/1

Understanding the activity and role of DarTG, a toxin:antitoxin system responsible for a novel DNA modification

NIGMS NIH HHS

Grant: R01 GM067945

Biotechnology and Biological Sciences Research Council

Grant: BB/W016613/1

ADP-ribosylation of DNA in Mycobacterium tuberculosis

Wellcome Trust

Grant: 302632

ADP-ribosylation signalling in genome stability

National Institutes of Health

Grant: 5R01GM132129-02

Advancing Multiplexed Isobaric Tag-based Strategies for Proteome Profiling

National Institutes of Health

Grant: 2R01GM067945-14

New and Disruptive Technologies to Study Ubiquitin Biology through Sample Multiplexing

Wellcome Trust

Grant: 224095

Molecular mechanisms of cysteine ADP-ribosylation

Wellcome Trust

FWCI

3.73

Citation Percentile

0.9%

Citation Trend

2025

2026

hybridLicense: cc-by

journalhttps://www.pnas.org/doi/pdf/10.1073/pnas.2424985122

publisherhttps://www.pnas.org/doi/pdf/10.1073/pnas.2424985122

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2424985122

journalhttps://doi.org/10.1073/pnas.2424985122

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40493189

Fields of Study

PARP inhibition in cancer therapyComputational Drug Discovery MethodsInsect Resistance and Genetics0301 basic medicine03 medical and health sciencesReceptors, Aryl HydrocarbonHumansProteomePoly(ADP-ribose) PolymerasesProteomicsSuppressor of Cytokine Signaling 3 ProteinCell Line, TumorSignal TransductionCRISPR-Cas SystemsClustered Regularly Interspaced Short Palindromic RepeatsLung NeoplasmsNucleoside Transport ProteinsBasic Helix-Loop-Helix Proteins

MeSH Terms

Suppressor of Cytokine Signaling 3 ProteinHumansLung NeoplasmsPoly(ADP-ribose) PolymerasesSignal TransductionReceptors, Aryl HydrocarbonProteomeNucleoside Transport ProteinsProteomicsCell Line, TumorBasic Helix-Loop-Helix Transcription FactorsBasic Helix-Loop-Helix ProteinsClustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Cas Systems

Keywords

Aryl hydrocarbon receptorProteomeProteomicsCRISPRComputational biologyFunction (biology)BiologyChemistryBiochemistryCell biologyGenePARPAdp-ribosylationBasic Helix-Loop-Helix ProteinsLung NeoplasmsNucleoside Transport ProteinsBiological SciencesReceptors, Aryl HydrocarbonSuppressor of Cytokine Signaling 3 ProteinCell Line, TumorHumansClustered Regularly Interspaced Short Palindromic RepeatsPoly(ADP-ribose) PolymerasesCRISPR-Cas SystemsSignal Transduction

Sustainable Development Goals

SDG 0: Good health and well-being

CRISPR screens and quantitative proteomics reveal remodeling of the aryl hydrocarbon receptor–driven proteome through PARP7 activity

FAIR Checklist

Authors (14)

Funding (18 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)