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Verapamil and its metabolite norverapamil inhibit the Mycobacterium tuberculosis MmpS5L5 efflux pump to increase bedaquiline activity

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2426827122Source: DataRank Database

Verapamil and its metabolite norverapamil inhibit the Mycobacterium tuberculosis MmpS5L5 efflux pump to increase bedaquiline activity is a research paper published in Proceedings of the National Academy of Sciences (2025). On theSindex it has a DataRank of 0.442. It has been cited 18 times.

N/A

0.442DataRank · unranked

Scored on demand from live citation data

Open Access18 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (6 grants)Impact (FWCI 13.46)OA: hybridTopics (46)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.442

From this paper's citation signal

Citation Network Contribution

Citation network not refreshed for this result

This paper's DataRank is currently driven only by its base citation score. Citation network data was not refreshed for this result.

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Authors (10)

Natalie J.E. Waller ORCID,Chen‐Yi Cheung ORCID,William J Jowsey,Michael T Chrisp,Mark Troll ORCID

Live enrichment

PubMed:40244664 PMC:PMC12036985 OpenAlex:https://openalex.org/W4409538629

Wellcome Trust

Grant: 223103/Z/21/Z

Foundation for the NIH

Grant: R37 AI054503

Maurice Wilkins Centre for Molecular Biodiscovery and the Marsden Fund

Grant: UOO1807

NIAID NIH HHS

Grant: R01 AI054503

Wellcome Trust

Grant: 223103

Innate immunity and inflammation in tuberculosis: insights from the zebrafish and therapeutic opportunities

National Institutes of Health

Grant: 5R01AI054503-21

Host responses to Mycobacterium infection in Zebrafish

FWCI

13.46

Citation Percentile

1.0%

Citation Trend

2025

2026

hybridLicense: cc-by

journalhttps://www.pnas.org/doi/pdf/10.1073/pnas.2426827122

publisherhttps://www.pnas.org/doi/pdf/10.1073/pnas.2426827122

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2426827122

journalhttps://doi.org/10.1073/pnas.2426827122

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40244664

Fields of Study

Tuberculosis Research and EpidemiologyAntibiotic Resistance in BacteriaDrug Transport and Resistance MechanismsMycobacterium tuberculosisDiarylquinolinesVerapamilAntitubercular AgentsBacterial ProteinsMicrobial Sensitivity TestsMembrane Transport ProteinsDrug Resistance, Bacterial

MeSH Terms

Antitubercular AgentsBacterial ProteinsMicrobial Sensitivity TestsMycobacterium tuberculosisVerapamilDrug Resistance, BacterialMembrane Transport ProteinsDiarylquinolines

Keywords

BedaquilineVerapamilEffluxPharmacologyChemistryClofazimineMultiple drug resistanceMetaboliteMycobacterium tuberculosisDrug resistanceTuberculosisMicrobiologyBiologyMedicineCalciumBiochemistryImmunologyMmps5l5 Drug Efflux PumpTbaj-587 And Tbaj-876Verapamil And NorverapamilBacterial ProteinsDrug Resistance, BacterialAntitubercular AgentsMembrane Transport ProteinsMicrobial Sensitivity TestsBiological SciencesDiarylquinolines

Sustainable Development Goals

SDG 0: Good health and well-being