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Structural insights into the activation and inhibition of the ADAM17–iRhom2 complex

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2500732122Source: DataRank Database

Structural insights into the activation and inhibition of the ADAM17–iRhom2 complex is a research paper published in Proceedings of the National Academy of Sciences (2025). On theSindex it has a DataRank of 0. It has been cited 3 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access3 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (8 grants)Impact (FWCI 2.31)OA: hybridTopics (38)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (8)

Conner E. Slone,Hala F. Alnajjar,MARIA F. RICH,Bryce Guion,Igal Ifergan ORCID

Live enrichment

PubMed:40512800 OpenAlex:https://openalex.org/W4411272793

HHS | NIH | National Institute of General Medical Sciences

Grant: R35GM146830

HHS | NIH | National Institute of General Medical Sciences

Grant: R35GM134907

HHS | NIH | National Institute of General Medical Sciences

Grant: R35GM146890

National Institutes of Health

Grant: 5R35GM146830-04

Structure and Regulation of Ectodomain Sheddases in Development and Disease

National Institutes of Health

Grant: 3R35GM146890-02S1

Role of the neurovascular molecule Wnt in regulating CNS inflammatory responses

National Institutes of Health

Grant: 1S10OD030388-01

Glacios 200 kV cryogenic transmission electron microscope (cryo-TEM)

National Institutes of Health

Grant: 5R35GM134907-04

Role of iRhoms and ADAM17 in EGFR and TNFalpha signaling

NIH HHS

Grant: S10 OD030388

FWCI

2.31

Citation Percentile

0.9%

Citation Trend

2025

2026

hybridLicense: cc-by

journalhttps://www.pnas.org/doi/pdf/10.1073/pnas.2500732122

publisherhttps://www.pnas.org/doi/pdf/10.1073/pnas.2500732122

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2500732122

journalhttps://doi.org/10.1073/pnas.2500732122

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40512800

Fields of Study

HER2/EGFR in Cancer ResearchPeptidase Inhibition and AnalysisMonoclonal and Polyclonal Antibodies Research0301 basic medicine03 medical and health sciencesADAM17 ProteinHumansCryoelectron MicroscopyProtein BindingCarrier ProteinsSARS-CoV-2DioxygenasesModels, MolecularIntracellular Signaling Peptides and Proteins

MeSH Terms

ADAM17 ProteinSARS-CoV-2Carrier ProteinsHumansModels, MolecularProtein BindingCryoelectron MicroscopyIntracellular Signaling Peptides and ProteinsDioxygenases

Keywords

ChemistryModels, MolecularSARS-CoV-2Cryoelectron MicroscopyIntracellular Signaling Peptides and ProteinsHumansBiological SciencesADAM17 ProteinCarrier ProteinsProtein BindingDioxygenasesADAM17ectodomain sheddingiRhom2immunity

Sustainable Development Goals

SDG 0: Good health and well-being